SETD8 methylates TP53

Stable Identifier
R-HSA-6805740
Type
Reaction
Species
Homo sapiens
Compartment
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The protein lysine methyltransferase SETD8 (SET8) monomethylates TP53 (p53) on lysine residue K382, resulting in repression of TP53 transcriptional activity (Shi et al. 2007).

Literature References
PubMed ID Title Journal Year
17707234 Modulation of p53 function by SET8-mediated methylation at lysine 382

Wang, EW, Kachirskaia, I, Dutta, S, Appella, E, Wen, H, Gozani, O, Yamaguchi, H, Shi, X, West, LE

Mol. Cell 2007
Participants
Participates
Catalyst Activity

lysine N-methyltransferase activity of SETD8 [nucleoplasm]

Orthologous Events
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