SETD8 methylates TP53

Stable Identifier
R-HSA-6805740
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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SETD8 methylates TP53
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The protein lysine methyltransferase SETD8 (SET8) monomethylates TP53 (p53) on lysine residue K382, resulting in repression of TP53 transcriptional activity (Shi et al. 2007).

Literature References
PubMed ID Title Journal Year
17707234 Modulation of p53 function by SET8-mediated methylation at lysine 382

Shi, X, Kachirskaia, I, Yamaguchi, H, West, LE, Wen, H, Wang, EW, Dutta, S, Appella, E, Gozani, O

Mol. Cell 2007
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
lysine N-methyltransferase activity of SETD8 [nucleoplasm]
Physical Entity
SETD8 [nucleoplasm]
Activity
lysine N-methyltransferase activity (0016278)
Orthologous Events
SETD8 methylates TP53 (Bos taurus)
SETD8 methylates TP53 (Danio rerio)
SETD8 methylates TP53 (Drosophila melanogaster)
SETD8 methylates TP53 (Mus musculus)
SETD8 methylates TP53 (Rattus norvegicus)
SETD8 methylates TP53 (Sus scrofa)
SETD8 methylates TP53 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-20)