Protein arginine methyltransferase PRMT5, recruited to TP53 (p53) by TTC5 (Strap), monomethylates TP53 on arginine residue R333 and dimethylates TP53 arginine residues R335 and R337. PRMT5-mediated methylation of TP53 modulates the affinity of TP53 for target promoters, promoting expression of cell cycle arrest genes rather than cell death genes (Jansson et al. 2008).
La Thangue, NB,
protein-arginine omega-N symmetric methyltransferase activity of p-S15,S20-TP53 Tetramer:p-S203,S221-TTC5:EP300:JMY:PRMT5 [nucleoplasm]