PRMT5 methylates TP53

Stable Identifier
R-HSA-6804383
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PRMT5 methylates TP53
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Protein arginine methyltransferase PRMT5, recruited to TP53 (p53) by TTC5 (Strap), monomethylates TP53 on arginine residue R333 and dimethylates TP53 arginine residues R335 and R337. PRMT5-mediated methylation of TP53 modulates the affinity of TP53 for target promoters, promoting expression of cell cycle arrest genes rather than cell death genes (Jansson et al. 2008).
Literature References
PubMed ID Title Journal Year
19011621 Arginine methylation regulates the p53 response

Cho, EC, Edelmann, M, Jansson, M, La Thangue, NB, Durant, ST, Kessler, B, Sheahan, S

Nat. Cell Biol. 2008
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Catalyst Activity

protein-arginine omega-N symmetric methyltransferase activity of p-S15,S20-TP53 Tetramer:p-S203,S221-TTC5:EP300:JMY:PRMT5 [nucleoplasm]

Physical Entity
p-S15,S20-TP53 Tetramer:p-S203,S221-TTC5:EP300:JMY:PRMT5 [nucleoplasm] (Homo sapiens)
Activity
protein-arginine omega-N symmetric methyltransferase activity (GO:0035243)
Orthologous Events
PRMT5 methylates TP53 (Bos taurus)
PRMT5 methylates TP53 (Canis familiaris)
PRMT5 methylates TP53 (Danio rerio)
PRMT5 methylates TP53 (Mus musculus)
PRMT5 methylates TP53 (Rattus norvegicus)
PRMT5 methylates TP53 (Sus scrofa)
PRMT5 methylates TP53 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-09)
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