Reactome | PLK2 phosphorylates CENPJ

PLK2 phosphorylates CENPJ

Stable Identifier

R-HSA-6801666

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)
        
        PLK2 phosphorylates CENPJ (Homo sapiens)

General

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PLK2 phosphorylates centrosome protein CENPJ (CPAP) on serine residues S589 and S585, which is a prerequisite for procentriole formation and centrosome duplication (Chang et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20531387	PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle Chang, J, Cizmecioglu, O, Hoffmann, I, Rhee, K	EMBO J.	2010

Participants

Input

Output

Participant Of

hasEvent

TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Catalyst Activity

Title

protein serine/threonine kinase activity of PLK2 [cytosol]

Physical Entity

PLK2 [cytosol]

Activity

protein serine/threonine kinase activity (0004674)

Orthologous Events

PLK2 phosphorylates CENPJ (Bos taurus)

PLK2 phosphorylates CENPJ (Canis familiaris)

PLK2 phosphorylates CENPJ (Danio rerio)

PLK2 phosphorylates CENPJ (Gallus gallus)

PLK2 phosphorylates CENPJ (Mus musculus)

PLK2 phosphorylates CENPJ (Rattus norvegicus)

PLK2 phosphorylates CENPJ (Sus scrofa)

PLK2 phosphorylates CENPJ (Xenopus tropicalis)

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-10-02)