PIDD1 translocates to the cytosol

Stable Identifier
R-HSA-6800793
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PIDD1 can localize both to the nucleus and to the cytoplasm. It is not known whether ATM-mediated phosphorylation regulates PIDD1 localization, but PIDDosome formation and caspase-2 activation is thought to be predominantly cytoplasmic (Ando et al. 2012).

Literature References
PubMed ID Title Journal Year
22854598 PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling

Ando, K, Kernan, JL, Liu, PH, Sanda, T, Logette, E, Tschopp, J, Look, AT, Wang, J, Bouchier-Hayes, L, Sidi, S

Mol. Cell 2012
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created