PIDD1 translocates to the cytosol

Stable Identifier
R-HSA-6800793
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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PIDD1 translocates to the cytosol
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PIDD1 can localize both to the nucleus and to the cytoplasm. It is not known whether ATM-mediated phosphorylation regulates PIDD1 localization, but PIDDosome formation and caspase-2 activation is thought to be predominantly cytoplasmic (Ando et al. 2012).
Literature References
PubMed ID Title Journal Year
22854598 PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling

Sanda, T, Liu, PH, Wang, J, Look, AT, Logette, E, Bouchier-Hayes, L, Kernan, JL, Tschopp, J, Ando, K, Sidi, S

Mol. Cell 2012
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Orthologous Events
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PIDD1 translocates to the cytosol (Sus scrofa)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-29)
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