Reactome | PIDD1 translocates to the cytosol

PIDD1 translocates to the cytosol

Stable Identifier

R-HSA-6800793

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Caspase Activators and Caspases (Homo sapiens)
        
        PIDD1 translocates to the cytosol (Homo sapiens)

General

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PIDD1 can localize both to the nucleus and to the cytoplasm. It is not known whether ATM-mediated phosphorylation regulates PIDD1 localization, but PIDDosome formation and caspase-2 activation is thought to be predominantly cytoplasmic (Ando et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22854598	PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling Sanda, T, Liu, PH, Wang, J, Look, AT, Logette, E, Bouchier-Hayes, L, Kernan, JL, Tschopp, J, Ando, K, Sidi, S	Mol. Cell	2012