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IL1RAP-1 [plasma membrane]
Stable Identifier
R-HSA-445745
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
mIL1RAP, Interleukin-1 receptor accessory protein, membrane associated isoform, mIL-1RAcP, IL-1RAcP, IL1AP_HUMAN, Membrane-bound IL-1RAcP, IL1RAP isoform 1, IL-1R3
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
Hyperphosphorylated IRAK1 associates with TRAF6 (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP binds MYD88 homodimer (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
IRAK1 binds to MYD88 within the IL1R complex (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
IRAK4 is activated by autophosphorylation (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
IRAK4 phosphorylates IRAK1 (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
IRAK4-activated IRAK1 autophosphorylates (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
TRAF6 binding leads to IRAK1:TRAF6 release (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
The Interleukin 1 receptor complex binds Tollip (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
Interleukin-33 signaling (Homo sapiens)
IL33:IL1RL1 binds IL1RAP-1 (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
IL33:IL1RL1:IL1RAP-1 [plasma membrane] (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
Interleukin-36 pathway (Homo sapiens)
IL36:IL1RL2 binds IL1RAP-1 (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
IL36:IL1RL2:IL1RAP-1 [plasma membrane] (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Protein-protein interactions at synapses (Homo sapiens)
Receptor-type tyrosine-protein phosphatases (Homo sapiens)
PTPRD binds IL1RAP-1 (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
PTPRD:IL1RAP-1 [plasma membrane] (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Homo sapiens)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Homo sapiens)
IL33:IL1RL1:IL1RAP-1 [plasma membrane] (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Homo sapiens)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Homo sapiens)
IL33:IL1RL1:IL1RAP-1 [plasma membrane] (Homo sapiens)
IL1RAP-1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NPH3-1 IL1RAP
Gene Names
IL1RAP, C3orf13, IL1R3
Other Identifiers
11729098_a_at
11729099_a_at
11732585_a_at
11761995_a_at
16949584
16949611
205227_PM_at
205227_at
210233_PM_at
210233_at
2657835
2657836
2657841
2657845
2657848
2657849
2657850
2657857
2657858
2657859
2657860
2657861
2657862
2657865
2657866
2657867
2657872
2657873
2657874
2657875
2657876
2657881
2657882
2657883
2657884
2657885
2657886
2657887
2657888
2657889
2657890
2657891
2657892
2657893
3556
38546_at
51136_at
61531_at
8084794
A_14_P111968
A_14_P137472
A_21_P0000070
A_23_P170857
A_23_P336554
A_24_P148762
A_24_P180165
GE53127
GE900526
GE903664
GO:0002114
GO:0002376
GO:0003824
GO:0003953
GO:0004908
GO:0005149
GO:0005576
GO:0005886
GO:0006954
GO:0006955
GO:0007155
GO:0007165
GO:0015026
GO:0016020
GO:0016787
GO:0019221
GO:0023052
GO:0032736
GO:0032753
GO:0032754
GO:0032755
GO:0038172
GO:0045087
GO:0045202
GO:0051965
GO:0060089
GO:0061809
GO:0065003
GO:0070498
GO:0098542
GO:0098978
GO:0099151
GO:0099545
GO:0099560
GO:1905606
HMNXSV003033302
HMNXSV003037537
HMNXSV003050674
ILMN_1686884
ILMN_1793870
ILMN_2357062
PH_hs_0022571
TC03001048.hg
g4504660_3p_x_at
g8050486_3p_at
Participates
as a component of
PTPRD:IL1RAP-1 [plasma membrane] (Homo sapiens)
IL36:IL1RL2:IL1RAP-1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL33:IL1RL1:IL1RAP-1 [plasma membrane] (Homo sapiens)
as an input of
PTPRD binds IL1RAP-1 (Homo sapiens)
IL36:IL1RL2 binds IL1RAP-1 (Homo sapiens)
IL33:IL1RL1 binds IL1RAP-1 (Homo sapiens)
Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Homo sapiens)
Inferred To
IL1RAP-1 [plasma membrane]
(Bos taurus)
IL1RAP-1 [plasma membrane]
(Gallus gallus)
Ghost homologue of IL1RAP-1 [plasma membrane]
(Sus scrofa)
il1rap [plasma membrane]
(Xenopus tropicalis)
Il1rap [plasma membrane]
(Mus musculus)
Il1rap [plasma membrane]
(Rattus norvegicus)
IL1RAP [plasma membrane]
(Canis familiaris)
Cross References
RefSeq
NP_002173.1
,
NP_001161400.1
,
NP_001161402.1
,
NP_608273.1
,
NP_001161403.1
,
NP_001161401.1
OpenTargets
ENSG00000196083
ENSEMBL
ENSP00000072516
,
ENSP00000390541
,
ENST00000447382
,
ENST00000342550
,
ENSP00000401132
,
ENSP00000314807
,
ENSP00000387371
,
ENST00000439062
,
ENST00000422485
,
ENST00000422940
,
ENSP00000409352
,
ENST00000072516
,
ENST00000317757
,
ENSP00000416296
,
ENST00000413869
,
ENSP00000345829
IntEnz
3.2.2.6
HPA
ENSG00000196083-IL1RAP
PRO
Q9NPH3
Pharos - Targets
Q9NPH3
PDB
3O4O
,
4DEP
,
7FCC
HMDB Protein
HMDBP12401
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01584 IL1B
4
IL1B(1-269) [cytosol]
(R-HSA-448689)
IL1B(117-269) [cytosol]
(R-HSA-449046)
IL1B(1-116) [cytosol]
(R-HSA-449030)
IL1B [extracellular region]
(R-HSA-445748)
0.764
7
UniProt:P14778 IL1R1
1
IL1R1 [plasma membrane]
(R-HSA-197595)
0.656
3
UniProt:P27930 IL1R2
1
IL1R2 [plasma membrane]
(R-HSA-197598)
0.524
2
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