Reactome | p-HIPK2:PIN1 [nucleoplasm]

p-HIPK2:PIN1

Stable Identifier

R-HSA-6799392

Type

Complex

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
24145406	Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death	Proc. Natl. Acad. Sci. U.S.A.	2013
23000554	HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop	J Mol Cell Biol	2013

Participants

components

Participant Of

input

TP53INP1 and HIPK2 bind TP53

hasComponent

TP53INP1:p-HIPK2:PIN1:p-S15,S20-TP53 [nucleoplasm]

output

HIPK2 phosphorylates TP53

Inferred To

p-HIPK2:PIN1 [nucleoplasm] (Bos taurus)

p-HIPK2:PIN1 [nucleoplasm] (Canis familiaris)

p-HIPK2:PIN1 [nucleoplasm] (Danio rerio)

p-HIPK2:PIN1 [nucleoplasm] (Drosophila melanogaster)

p-HIPK2:PIN1 [nucleoplasm] (Gallus gallus)

p-HIPK2:PIN1 [nucleoplasm] (Mus musculus)

p-HIPK2:PIN1 [nucleoplasm] (Rattus norvegicus)

p-HIPK2:PIN1 [nucleoplasm] (Sus scrofa)

p-HIPK2:PIN1 [nucleoplasm] (Xenopus tropicalis)

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