Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Aspartate and asparagine metabolism
Stable Identifier
R-HSA-8963693
DOI
10.3180/R-HSA-8963693.2
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Aspartate and asparagine metabolism (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this pathway in the Pathway Browser
These reactions mediate the synthesis of aspartate and asparagine from glutamate, TCA cycle intermediates, and ammonia and and allow the utilization of carbon atoms from these amino acids for glucose synthesis under fasting conditions (Felig 1975; Owen et al. 1979).
Literature References
PubMed ID
Title
Journal
Year
1094924
Amino acid metabolism in man
Felig, P
Annu. Rev. Biochem.
1975
371355
Energy metabolism in feasting and fasting
Reichard, GA
,
Patel, MS
,
Boden, G
,
Owen, OE
Adv. Exp. Med. Biol.
1979
Participants
Events
SLC25A12,13 exchange L-Glu and L-Asp
(Homo sapiens)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp
(Homo sapiens)
GOT2 dimer transaminates L-Asp
(Homo sapiens)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]
(Homo sapiens)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]
(Homo sapiens)
ASPG hydrolyses L-Asn to L-Asp
(Homo sapiens)
ASPA deacetylates NAASP to acetate and L-aspartate
(Homo sapiens)
NAASP translocates from mitochondrial matrix to cytosol
(Homo sapiens)
NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAASP
(Homo sapiens)
PXLP-K333-GADL1 decarboxylates acidic AAs
(Homo sapiens)
NAALADases hydrolyse NAAG
(Homo sapiens)
Participates
as an event of
Metabolism of amino acids and derivatives (Homo sapiens)
Event Information
Go Biological Process
aspartate family amino acid metabolic process (0009066)
Orthologous Events
Aspartate and asparagine metabolism (Bos taurus)
Aspartate and asparagine metabolism (Caenorhabditis elegans)
Aspartate and asparagine metabolism (Canis familiaris)
Aspartate and asparagine metabolism (Danio rerio)
Aspartate and asparagine metabolism (Dictyostelium discoideum)
Aspartate and asparagine metabolism (Drosophila melanogaster)
Aspartate and asparagine metabolism (Gallus gallus)
Aspartate and asparagine metabolism (Mus musculus)
Aspartate and asparagine metabolism (Plasmodium falciparum)
Aspartate and asparagine metabolism (Rattus norvegicus)
Aspartate and asparagine metabolism (Saccharomyces cerevisiae)
Aspartate and asparagine metabolism (Schizosaccharomyces pombe)
Aspartate and asparagine metabolism (Sus scrofa)
Aspartate and asparagine metabolism (Xenopus tropicalis)
Authored
Jassal, B (2017-02-10)
Created
Jassal, B (2017-02-10)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text