28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW [nucleoplasm]

Stable Identifier
R-HSA-6791568
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
17353269 Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit

Gruber-Eber, A, Harasim, T, Grimm, T, Malamoussi, A, Eick, D, Orban, M, Rohrmoser, M, Kremmer, E, Pfisterer, I, Hölzel, M

Mol. Cell. Biol. 2007
16738141 Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex

Gruber-Eber, A, Harasim, T, Grimm, T, Malamoussi, A, Eick, D, Rohrmoser, M, Kremmer, E, Hölzel, M

Nucleic Acids Res. 2006
16043514 Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation

Gruber-Eber, A, Schlee, M, Harasim, T, Grimm, T, Malamoussi, A, Eick, D, Bornkamm, GW, Rohrmoser, M, Hiddemann, W, Kremmer, E, Hölzel, M

J. Cell Biol. 2005
17189298 The BRCT domain of mammalian Pes1 is crucial for nucleolar localization and rRNA processing

Gruber-Eber, A, Harasim, T, Grimm, T, Malamoussi, A, Eick, D, Rohrmoser, M, Kremmer, E, Hölzel, M

Nucleic Acids Res. 2007
22190735 LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis

Denicourt, C, Cassimere, EK, Castle, CD

Mol. Biol. Cell 2012
Participants
components
Participates
as an input of
as an output of
Inferred To
28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW [nucleoplasm] (Bos taurus)
28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW [nucleoplasm] (Caenorhabditis elegans)
28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW [nucleoplasm] (Canis familiaris)
28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW [nucleoplasm] (Dictyostelium discoideum)
28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW [nucleoplasm] (Drosophila melanogaster)
28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW [nucleoplasm] (Mus musculus)
28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW [nucleoplasm] (Rattus norvegicus)
28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW [nucleoplasm] (Saccharomyces cerevisiae)
28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW [nucleoplasm] (Schizosaccharomyces pombe)
28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW [nucleoplasm] (Sus scrofa)
28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW [nucleoplasm] (Xenopus tropicalis)
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