12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The 12S pre-rRNA is nucleolytically cleaved to yield 5.8S rRNA. C1D, MPHOSPH6 (MPP6), and EXOSC10 (Pm/Scl-100) of the exosome associate and, together with SKIV2L2 (MTR4), are required for 3' processing of mature 5.8S rRNA therefore the exonuclease activity of the exosome seems to be involved (Schilders et al. 2007). Similarly, the DIS3 subunit of the nuclear exosome is required for production of 5.8S rRNA (Tomecki et al. 2010) and the 3'-5' exoribonuclease ISG20L2 (Coute et al. 2008) are also required for production of 5.8S rRNA from 12S pre-rRNA. As inferred from the mouse homolog, the 3'-5' exonuclease ERI1 also plays a role in trimming the 3' end of pre-5.8S rRNA (Ansel et al. 2008).
Literature References
PubMed ID Title Journal Year
20531386 The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L

Pastula, A, Kristiansen, MS, Dziembowski, A, Larsen, KM, Andersen, JS, Tomecki, R, Jensen, TH, Chlebowski, A, Stepien, PP, Szczesny, RJ, Drazkowska, K, Lykke-Andersen, S

EMBO J. 2010
18438418 Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing

Rao, A, Heissmeyer, V, Pastor, WA, Ansel, KM, Smith, LC, Glasmacher, E, Kremmer, E, Lamperti, ED, Ellwart, JW, Papadopoulou, N, Wolf, C, Rath, N, Shi, Y, Tahiliani, M, Lapan, AD

Nat. Struct. Mol. Biol. 2008
17412707 C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing

Schilders, G, van Dijk, E, Pruijn, GJ

Nucleic Acids Res. 2007
18065403 ISG20L2, a novel vertebrate nucleolar exoribonuclease involved in ribosome biogenesis

Sanchez, JC, Duret, L, Belin, S, Bezin, L, Diaz, JJ, Dieckmann, R, Couté, Y, Kindbeiter, K

Mol. Cell Proteomics 2008
This event is regulated
Orthologous Events
Cite Us!