KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1

Stable Identifier
R-HSA-6786205
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Calmodulin (CALM1) is a ubiquitous key mediator of Ca2+-dependent signalling and is subject to regulatory post-translational modifications which can affect protein-protein interactions. CALM1 is frequently trimethylated at Lys-115 which can influence changes in growth and development and its activator properties with target enzymes. The cytosolic enzyme calmodulin-lysine N-methyltransferase (CAMKMT) catalyses the transfer of 3 methyl groups from high energy donors S-adenosyl-L-methionine (AdoMet) to lysine residue 115 in CALM1, forming a trimethylated protein (triMe-K115-CALM1) (Magnani et al. 2010).

Literature References
PubMed ID Title Journal Year
20975703 Calmodulin methyltransferase is an evolutionarily conserved enzyme that trimethylates Lys-115 in calmodulin

Magnani, R, Dirk, LM, Trievel, RC, Houtz, RL

Nat Commun 2010
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Catalyst Activity
Title
calmodulin-lysine N-methyltransferase activity of CAMKMT [cytosol]
Physical Entity
Activity
Orthologous Events
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