Protein methylation

Stable Identifier
R-HSA-8876725
DOI
10.3180/R-HSA-8876725.1
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Protein methylation
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Methylation of lysine (Lys) and arginine (Arg) residues on non-histone proteins is a prevalent post-translational modification and important regulator of cellular signal transduction pathways including MAPK, WNT, BMP, Hippo and JAK–STAT. Crosstalk between methylation and other types of post-translational modifications and between histone and non-histone protein methylation is frequent, affecting cellular functions such as chromatin remodelling, gene transcription, protein synthesis, signal transduction and DNA repair (Biggar & Li 2015).
Literature References
PubMed ID Title Journal Year
25491103 Non-histone protein methylation as a regulator of cellular signalling and function

Biggar, KK, Li, SS

Nat. Rev. Mol. Cell Biol. 2015
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Event Information
Go Biological Process
protein methylation (0006479)
Orthologous Events
Protein methylation (Bos taurus)
Protein methylation (Caenorhabditis elegans)
Protein methylation (Canis familiaris)
Protein methylation (Danio rerio)
Protein methylation (Dictyostelium discoideum)
Protein methylation (Drosophila melanogaster)
Protein methylation (Gallus gallus)
Protein methylation (Mus musculus)
Protein methylation (Plasmodium falciparum)
Protein methylation (Rattus norvegicus)
Protein methylation (Saccharomyces cerevisiae)
Protein methylation (Schizosaccharomyces pombe)
Protein methylation (Sus scrofa)
Protein methylation (Xenopus tropicalis)
Authored
Jupe, S  (2016-06-16)
Reviewed
Falnes, PØ  (2016-10-10)
Created
Jupe, S  (2016-06-16)
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