Reactome | FA core complex assembles at DNA interstrand crosslinks (ICLs)

FA core complex assembles at DNA interstrand crosslinks (ICLs)

Stable Identifier

R-HSA-6785126

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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FA core complex assembles at DNA interstrand crosslinks (ICLs)

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In addition to FANCM, FAAP24, APITD1 (MHF1) and STRA13 (MHF2), the FA core complex also includes FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FAAP20 and FAAP100 (Singh et al. 2010, Yan et al. 2010, Leung et al. 2012). While FANCA, FANCB, FANCC, FANCE, FANCF, FANCG and FANCL, and probably FAAP20 and FAAP100, can assemble a complex in the nucleoplasm, they are unable to load onto DNA in the absence of FANCM and FAAP24 (Kim et al. 2008, Yan et al. 2010, Leung et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
18174376	Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24 Gurtan, A, D'Andrea, AD, Kim, JM, Kee, Y	Blood	2008
22396592	Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair Li, L, Leung, JW, Wang, Y, Fong, KW, Huen, MS, Chen, J	Proc. Natl. Acad. Sci. U.S.A.	2012
20347429	MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM Pierce, AJ, Singh, TR, Wahengbam, K, Ali, AM, Sachpatzidis, A, Zheng, XF, Meetei, AR, Du, CH, Sung, P, Killen, MW, Xiong, Y, Saro, D	Mol. Cell	2010
20347428	A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability Shen, X, Joenje, H, Constantinou, A, Sen, R, Daee, D, Oostra, AB, Décaillet, C, Stasiak, A, Stone, S, Hoatlin, ME, Wang, W, Steltenpool, J, Muniandy, PA, Osman, F, Myung, K, Whitby, MC, Schindler, D, Stasiak, AZ, Yan, Z, Lin, T, Seidman, MM, Li, L, Delannoy, M, Du, H, de Winter, JP, Ling, C, Schuster, B, Woodcock, CL	Mol. Cell	2010