LCMT2 methylates yW-72 yielding yW-58 at nucleotide 37 of tRNA(Phe)

Stable Identifier
R-HSA-6782881
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytoplasm
ReviewStatus
5/5
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LCMT2 methylates yW-72 yielding yW-58 at nucleotide 37 of tRNA(Phe)
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As inferred from homologues in Saccharomyces cerevisiae, LCMT2 (TYW4) transfers a methyl group from S-adenosylmethionine to yW-72 (7-((3S)-3-amino-3-carboxypropyl)wyosine) at nucleotide 37 of tRNA(Phe), yielding yW-58 (7-((3S)-3-amino-3-(methoxycarbonyl)propyl)wyosine) and S-adenosylhomocysteine.
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Output
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Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

tRNA methyltransferase activity of LCMT2 [cytoplasm]

Physical Entity
LCMT2 [cytoplasm] (Homo sapiens)
Activity
tRNA methyltransferase activity (GO:0008175)
Inferred From
PPM2 methylates yW-72 yielding yW-58 at nucleotide 37 of tRNA(Phe) (Saccharomyces cerevisiae)
Authored
May, B  (2015-06-08)
Reviewed
Levinger, L  (2015-08-11)
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-06-09)
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