PPM2 methylates yW-72 yielding yW-58 at nucleotide 37 of tRNA(Phe)

Stable Identifier
R-SCE-6783417
Type
Reaction [transition]
Species
Saccharomyces cerevisiae
Compartment
cytoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PPM2 methylates yW-72 yielding yW-58 at nucleotide 37 of tRNA(Phe)
PPM2 (TYW4) transfers a methyl group from S-adenosylmethionine to yW-72 (7-((3S)-3-amino-3-carboxypropyl)wyosine) at nucleotide 37 of tRNA(Phe), yielding yW-58 (7-((3S)-3-amino-3-(methoxycarbonyl)propyl)wyosine) and S-adenosylhomocysteine (Noma et al. 2006, Noma and Suzuki 2006, Suzuki et al. 2009).
Literature References
PubMed ID Title Journal Year
19287006 Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4

Suzuki, T, Noma, A, Nureki, O, Ishitani, R, Suzuki, Y

Nucleic Acids Res. 2009
17150819 Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis

Suzuki, T, Noma, A

Nucleic Acids Symp Ser (Oxf) 2006
16642040 Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA

Suzuki, T, Noma, A, Ikeuchi, Y, Kirino, Y

EMBO J. 2006
Participants
Input
Output
Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

tRNA methyltransferase activity of PPM2 [cytoplasm]

Physical Entity
PPM2 [cytoplasm] (Saccharomyces cerevisiae)
Activity
tRNA methyltransferase activity (GO:0008175)
Orthologous Events
LCMT2 methylates yW-72 yielding yW-58 at nucleotide 37 of tRNA(Phe) (Homo sapiens)
Authored
May, B  (2015-06-13)
Reviewed
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-06-15)
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