TRMT5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe)

Stable Identifier
R-HSA-6782859
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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TRMT5 transfers a methyl group from S-adenosylmethionine to the 1 position of guanosine-37 of tRNA(Phe) (Brulé et al. 2004, Christian et al. 2013). The yeast homolog, TRM5, catalyzes the same reaction.

Literature References
PubMed ID Title Journal Year
15248782 Isolation and characterization of the human tRNA-(N1G37) methyltransferase (TRM5) and comparison to the Escherichia coli TrmD protein

Brulé, H, Elliott, M, Redlak, M, Zehner, ZE, Holmes, WM

Biochemistry 2004
23887145 Conservation of structure and mechanism by Trm5 enzymes

Christian, T, Gamper, H, Hou, YM

RNA 2013
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Catalyst Activity
Title
tRNA (guanine-N1-)-methyltransferase activity of TRMT5 [nucleoplasm]
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