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XDH [cytosol]
Stable Identifier
R-HSA-67421
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Xanthine dehydrogenase/oxidase, Xanthine dehydrogenase , XD, Xanthine oxidase , XO, Xanthine oxidoreductase
Locations in the PathwayBrowser
Expand all
Drug ADME (Homo sapiens)
Azathioprine ADME (Homo sapiens)
XDH oxidises 6MP to 6TU (Homo sapiens)
XDH dimer [cytosol] (Homo sapiens)
XDH [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Butyrophilin (BTN) family interactions (Homo sapiens)
BTN1A1 binds xanthine oxidoreductase (XDH) (Homo sapiens)
BTN1A1:XDH [plasma membrane] (Homo sapiens)
XDH [cytosol] (Homo sapiens)
XDH [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Nucleotide catabolism (Homo sapiens)
Purine catabolism (Homo sapiens)
XDH dehydrogenates hypoxanthine to form xanthine (Homo sapiens)
XDH dimer [cytosol] (Homo sapiens)
XDH [cytosol] (Homo sapiens)
XDH dehydrogenates xanthine to form urate (Homo sapiens)
XDH dimer [cytosol] (Homo sapiens)
XDH [cytosol] (Homo sapiens)
XDH oxidizes hypoxanthine to form xanthine (Homo sapiens)
XDH dimer [cytosol] (Homo sapiens)
XDH [cytosol] (Homo sapiens)
XDH oxidizes xanthine to form urate (Homo sapiens)
XDH dimer [cytosol] (Homo sapiens)
XDH [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P47989 XDH
Gene Names
XDH, XDHA
Chain
chain:1-1333
Reference Genes
BioGPS Gene:7498 XDH
COSMIC (genes):XDH XDH
CTD Gene:7498 XDH
dbSNP Gene:7498 XDH
ENSEMBL:ENSG00000158125 XDH
HGNC:12805 XDH
KEGG:hsa:7498 XDH
Monarch:7498 XDH
NCBI Gene:7498 XDH
OMIM:607633 XDH
UCSC:P47989 XDH
Reference Transcript
RefSeq:NM_000379.3 XDH
Other Identifiers
11733464_at
11733465_at
16896196
210301_PM_at
210301_at
241994_PM_at
241994_at
2547129
2547130
2547131
2547136
2547138
2547139
2547140
2547141
2547143
2547147
2547148
2547149
2547150
2547151
2547152
2547153
2547154
2547155
2547156
2547158
2547159
2547160
2547161
2547162
2547163
2547164
2547165
2547170
2547173
2547174
2547176
2547177
2547178
2547181
2547183
2547187
2547190
2547192
2547193
2547194
2547200
2547204
2547205
33463_at
7498
76770_at
8051322
A_23_P39590
A_33_P3270863
GE62514
GO:0000255
GO:0001933
GO:0001937
GO:0003824
GO:0004854
GO:0004855
GO:0005506
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005777
GO:0005783
GO:0005829
GO:0006147
GO:0006148
GO:0006149
GO:0006154
GO:0006157
GO:0006161
GO:0006196
GO:0006204
GO:0006919
GO:0007595
GO:0009114
GO:0009115
GO:0010629
GO:0016226
GO:0016491
GO:0016529
GO:0030856
GO:0042803
GO:0043226
GO:0043546
GO:0043605
GO:0045602
GO:0046038
GO:0046055
GO:0046059
GO:0046872
GO:0050660
GO:0051536
GO:0051537
GO:0051898
GO:0055086
GO:0070674
GO:0070675
GO:0071949
GO:1900745
GO:1900747
GO:1901135
GO:2000379
GO:2001213
HMNXSV003049582
Hs.125376.0.A1_3p_at
ILMN_1712632
PH_hs_0000032
TC02001714.hg
U39487_at
g984266_3p_at
Participates
as a component of
BTN1A1:XDH [plasma membrane] (Homo sapiens)
XDH dimer [cytosol] (Homo sapiens)
as an input of
BTN1A1 binds xanthine oxidoreductase (XDH) (Homo sapiens)
Inferred To
XDH [cytosol]
(Bos taurus)
XDH [cytosol]
(Caenorhabditis elegans)
XDH [cytosol]
(Canis familiaris)
XDH [cytosol]
(Dictyostelium discoideum)
XDH [cytosol]
(Drosophila melanogaster)
XDH [cytosol]
(Gallus gallus)
XDH [cytosol]
(Mus musculus)
XDH [cytosol]
(Rattus norvegicus)
XDH [cytosol]
(Sus scrofa)
XDH [cytosol]
(Xenopus tropicalis)
Cross References
ZINC - World Drugs
XDH_HUMAN
Guide to Pharmacology - Targets
2646
ENSEMBL
ENSP00000368727
,
ENST00000379416
OpenTargets
ENSG00000158125
ZINC - FDA approved
XDH_HUMAN
ZINC - Substances
XDH_HUMAN
ZINC - Biogenic
XDH_HUMAN
ZINC target
P47989
PRO
P47989
PDB
2CKJ
,
2E1Q
ZINC - Investigational
XDH_HUMAN
ZINC - Metabolites
XDH_HUMAN
IntEnz
1.17.3.2
HPA
ENSG00000158125-XDH
Pharos - Targets
P47989
Orphanet
XDH
ZINC - Predictions - Purchasable
XDH_HUMAN
HMDB Protein
HMDBP00181
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y3R0-3 GRIP1
0.556
3
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