Reactome | BTN1A1 binds xanthine oxidoreductase (XDH)

BTN1A1 binds xanthine oxidoreductase (XDH)

Stable Identifier

R-HSA-8851044

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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BTN1A1 binds xanthine oxidoreductase (XDH)

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The B30.2 cytoplasmic domain (PRY/SPRY domain) of Butyrophilin 1A1 (BTN1A1) binds the enzyme xanthine oxidoreductase (XDH). This interaction provides scaffolding function, stabilizes the milk fat globule membrane (MFGM), and aids in milk fat globule secretion (Jeong et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
12502743	The housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary gland Vorbach, C, Capecchi, MR, Scriven, A	Genes Dev.	2002
19531472	The PRY/SPRY/B30.2 domain of butyrophilin 1A1 (BTN1A1) binds to xanthine oxidoreductase: implications for the function of BTN1A1 in the mammary gland and other tissues Hathout, Y, Mather, IH, Fenselau, C, Jeong, J, Xu, J, Ogg, SL, Rao, AU	J. Biol. Chem.	2009