Reactome | PLCB2 [cytosol]

PLCB2 [cytosol]

Stable Identifier

R-HSA-61695

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PLC beta 2, Phosphoinositide phospholipase C, PLC-beta-2, Phospholipase C-beta-2, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2

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Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of kainate receptors upon glutamate binding (Homo sapiens)
      - Presynaptic function of Kainate receptors (Homo sapiens)
        
        Activation of GRIK3 homomer (Homo sapiens)
        
        G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] (Homo sapiens)
        
        PLC-beta 1/2/3 [cytosol] (Homo sapiens)
        
        PLCB2 [cytosol] (Homo sapiens)
        
        Kainate receptor-glutamate-Gprotein complex [plasma membrane] (Homo sapiens)
        
        G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] (Homo sapiens)
        
        PLC-beta 1/2/3 [cytosol] (Homo sapiens)
        
        PLCB2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q00722 PLCB2

Gene Names

PLCB2

Chain

chain:1-1185

Reference Genes

BioGPS Gene:5330 PLCB2

COSMIC (genes):PLCB2 PLCB2

CTD Gene:5330 PLCB2

dbSNP Gene:5330 PLCB2

ENSEMBL:ENSG00000137841 PLCB2

HGNC:9055 PLCB2

KEGG Gene (Homo sapiens):5330 PLCB2

Monarch:5330 PLCB2

NCBI Gene:5330 PLCB2

OMIM:604114 PLCB2

UCSC:Q00722 PLCB2

Reference Transcript

Other Identifiers

0000770520

11722131_a_at

11750570_x_at

11754492_x_at

16807342

204046_at

210_at

3619329

3619330

3619331

3619332

3619333

3619334

3619335

3619337

3619338

3619340

3619342

3619344

3619345

3619346

3619348

3619349

3619351

3619352

3619353

3619354

3619356

3619359

3619360

3619361

3619362

3619363

3619364

3619365

3619367

3619369

3619370

3619371

3619372

3619373

3619379

3619380

3619381

3619382

3619383

3619384

3619385

3619387

3619388

5330

7987475

A_33_P3260614

GE81412

GO:0003674

GO:0004435

GO:0004629

GO:0005509

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0006629

GO:0006644

GO:0007165

GO:0007186

GO:0007202

GO:0007223

GO:0007267

GO:0008081

GO:0008150

GO:0009056

GO:0016042

GO:0016787

GO:0035556

GO:0043167

GO:0043647

GO:0044281

GO:0046488

GO:0046872

GO:0048015

GO:0050877

GO:0050913

HMNXSV003026215

HMNXSV003030001

ILMN_1724066

M95678_at

PH_hs_0017247

TC15001233.hg

g4758937_3p_at

Participates

as a candidate of

PLC beta1,2,3 [cytosol] (Homo sapiens)

as a member of

as a component of

PLCB2:Ca2+ [cytosol] (Homo sapiens)

Inferred To

plc [cytosol] (Dictyostelium discoideum)

PLC1 [cytosol] (Saccharomyces cerevisiae)

Plcb2 [cytosol] (Mus musculus)

Plcb2 [cytosol] (Rattus norvegicus)

PLCB2 [cytosol] (Bos taurus)

PLCB2 [cytosol] (Canis familiaris)

PLCB2 [cytosol] (Gallus gallus)

PLCB2 [cytosol] (Plasmodium falciparum)

PLCB2 [cytosol] (Sus scrofa)

plc1 [cytosol] (Schizosaccharomyces pombe)

Plc21C [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001271227.1, NP_001271226.1, NP_004564.2

Guide to Pharmacology - Targets

1404

OpenTargets

ENSG00000137841

IntEnz

3.1.4.11

GeneCards

Q00722

HPA

ENSG00000137841-PLCB2

Ensembl

ENSP00000453975, ENST00000456256, ENSP00000411991, ENST00000260402, ENSG00000137841, ENSP00000260402, ENST00000557821

PRO

Q00722

Pharos - Targets

Q00722

Orphanet

26404

HMDB Protein

HMDBP00224

PDB

2FJU, 2ZKM

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