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PLCB2 [cytosol]
Stable Identifier
R-HSA-61695
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PLC beta 2, Phosphoinositide phospholipase C, PLC-beta-2, Phospholipase C-beta-2, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Inositol phosphate metabolism (Homo sapiens)
Synthesis of IP3 and IP4 in the cytosol (Homo sapiens)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Homo sapiens)
PLCbz [cytosol] (Homo sapiens)
PLCB2:Ca2+ [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Acetylcholine regulates insulin secretion (Homo sapiens)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Homo sapiens)
PLC beta1,2,3:G-alpha(q):GTP [plasma membrane] (Homo sapiens)
PLC beta1,2,3 [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
Gq alpha activates Phospholipase C beta (Homo sapiens)
PLC beta1,2,3 [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
PLC beta1,2,3:G-alpha(q):GTP [plasma membrane] (Homo sapiens)
PLC beta1,2,3 [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
Free fatty acids regulate insulin secretion (Homo sapiens)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Homo sapiens)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Homo sapiens)
PLC beta1,2,3:G-alpha(q):GTP [plasma membrane] (Homo sapiens)
PLC beta1,2,3 [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
Gq alpha activates Phospholipase C beta (Homo sapiens)
PLC beta1,2,3 [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
PLC beta1,2,3:G-alpha(q):GTP [plasma membrane] (Homo sapiens)
PLC beta1,2,3 [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of kainate receptors upon glutamate binding (Homo sapiens)
Presynaptic function of Kainate receptors (Homo sapiens)
Activation of GRIK3 homomer (Homo sapiens)
G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] (Homo sapiens)
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
Kainate receptor-glutamate-Gprotein complex [plasma membrane] (Homo sapiens)
G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] (Homo sapiens)
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
Sensory Perception (Homo sapiens)
Sensory perception of taste (Homo sapiens)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Homo sapiens)
GNB1,3:GNG13 binds PLCB2:Ca2+ (Homo sapiens)
GNB1,3:GNG13:PLCB2:Ca2+ [plasma membrane] (Homo sapiens)
PLCB2:Ca2+ [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
PLCB2:Ca2+ [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
GNB1,3:GNG13:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG (Homo sapiens)
GNB1,3:GNG13:PLCB2:Ca2+ [plasma membrane] (Homo sapiens)
PLCB2:Ca2+ [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein mediated events (Homo sapiens)
PLC beta mediated events (Homo sapiens)
Activation of PLC beta-1/4 (Homo sapiens)
Activated PLC beta 1/4 [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
Inactivation of PLC beta (Homo sapiens)
Activated PLC beta 1/4 [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
PIP2 hydrolysis (Homo sapiens)
Activated PLC beta 1/4 [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
PLC beta is activated by G alpha (q) (Homo sapiens)
PLC beta:G alpha (q/11) [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Homo sapiens)
PLC beta:G alpha (q/11) [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane] (Homo sapiens)
PLC beta:G alpha (q/11) [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Homo sapiens)
PLC beta:G alpha (q/11) [plasma membrane] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
G-protein beta:gamma signalling (Homo sapiens)
G beta:gamma signalling through PLC beta (Homo sapiens)
Gbeta:gamma activation of PLC beta (Homo sapiens)
G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] (Homo sapiens)
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
PLC beta-mediated PIP2 hydrolysis (Homo sapiens)
G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] (Homo sapiens)
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
Ca2+ pathway (Homo sapiens)
Gbeta:gamma activation of PLC beta (Homo sapiens)
G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] (Homo sapiens)
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
PLC beta-mediated PIP2 hydrolysis (Homo sapiens)
G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] (Homo sapiens)
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLCB2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q00722 PLCB2
Gene Names
PLCB2
Chain
chain:1-1185
Reference Genes
BioGPS Gene:5330 PLCB2
COSMIC (genes):PLCB2 PLCB2
CTD Gene:5330 PLCB2
dbSNP Gene:5330 PLCB2
ENSEMBL:ENSG00000137841.12 PLCB2
HGNC:9055 PLCB2
KEGG Gene (Homo sapiens):5330 PLCB2
Monarch:5330 PLCB2
NCBI Gene:5330 PLCB2
OMIM:604114 PLCB2
UCSC:Q00722 PLCB2
Reference Transcript
RefSeq:NM_001284298.1 PLCB2
RefSeq:NM_004573.2 PLCB2
RefSeq:NM_001284297.1 PLCB2
Other Identifiers
0000770520
11722131_a_at
11750570_x_at
11754492_x_at
16807342
204046_PM_at
204046_at
210_at
3619329
3619330
3619331
3619332
3619333
3619334
3619335
3619337
3619338
3619340
3619342
3619344
3619345
3619346
3619348
3619349
3619351
3619352
3619353
3619354
3619356
3619359
3619360
3619361
3619362
3619363
3619364
3619365
3619367
3619369
3619370
3619371
3619372
3619373
3619379
3619380
3619381
3619382
3619383
3619384
3619385
3619387
3619388
5330
7987475
A_33_P3260614
GE81412
GO:0001580
GO:0004435
GO:0004629
GO:0005509
GO:0005515
GO:0005543
GO:0005622
GO:0005737
GO:0005794
GO:0005829
GO:0005886
GO:0006629
GO:0006644
GO:0007165
GO:0007186
GO:0007200
GO:0007202
GO:0008081
GO:0008289
GO:0016042
GO:0016787
GO:0023052
GO:0031680
GO:0031683
GO:0032991
GO:0035556
GO:0043226
GO:0046488
GO:0046872
GO:0048015
GO:0050877
GO:0050913
HMNXSV003026215
HMNXSV003030001
ILMN_1724066
M95678_at
PH_hs_0017247
TC15001233.hg
g4758937_3p_at
Participates
as a candidate of
PLC beta1,2,3 [cytosol] (Homo sapiens)
as a member of
PLC-beta 1/2/3 [cytosol] (Homo sapiens)
PLC-beta [cytosol] (Homo sapiens)
as a component of
PLCB2:Ca2+ [cytosol] (Homo sapiens)
Inferred To
plcb2 [cytosol]
(Xenopus tropicalis)
PLCB2 [cytosol]
(Bos taurus)
PLCB2 [cytosol]
(Canis familiaris)
PLCB2 [cytosol]
(Dictyostelium discoideum)
PLCB2 [cytosol]
(Drosophila melanogaster)
PLCB2 [cytosol]
(Gallus gallus)
PLCB2 [cytosol]
(Mus musculus)
PLCB2 [cytosol]
(Plasmodium falciparum)
PLCB2 [cytosol]
(Rattus norvegicus)
PLCB2 [cytosol]
(Saccharomyces cerevisiae)
PLCB2 [cytosol]
(Schizosaccharomyces pombe)
PLCB2 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001271227.1
,
NP_001271226.1
,
NP_004564.2
Guide to Pharmacology - Targets
1404
OpenTargets
ENSG00000137841
IntEnz
3.1.4.11
GeneCards
Q00722
HPA
ENSG00000137841-PLCB2
Ensembl
ENST00000260402
,
ENST00000557821
,
ENST00000456256
,
ENSP00000411991
,
ENSP00000453975
,
ENSG00000137841
,
ENSP00000260402
PRO
Q00722
Pharos - Targets
Q00722
Orphanet
26404
HMDB Protein
HMDBP00224
PDB
2FJU
,
2ZKM
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