Reactome | PLCB2 [cytosol]

PLCB2 [cytosol]

Stable Identifier

R-HSA-61695

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PLC beta 2, Phosphoinositide phospholipase C, PLC-beta-2, Phospholipase C-beta-2, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2

Icon

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of kainate receptors upon glutamate binding (Homo sapiens)
      - Presynaptic function of Kainate receptors (Homo sapiens)
        
        Activation of GRIK3 homomer (Homo sapiens)
        
        G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] (Homo sapiens)
        
        PLC-beta 1/2/3 [cytosol] (Homo sapiens)
        
        PLCB2 [cytosol] (Homo sapiens)
        
        Kainate receptor-glutamate-Gprotein complex [plasma membrane] (Homo sapiens)
        
        G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] (Homo sapiens)
        
        PLC-beta 1/2/3 [cytosol] (Homo sapiens)
        
        PLCB2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q00722 PLCB2

Gene Names

PLCB2

Chain

chain:1-1185

Reference Genes

BioGPS Gene:5330 PLCB2

COSMIC (genes):PLCB2 PLCB2

CTD Gene:5330 PLCB2

dbSNP Gene:5330 PLCB2

ENSEMBL:ENSG00000137841 PLCB2

HGNC:9055 PLCB2

KEGG:hsa:5330 PLCB2

Monarch:5330 PLCB2

NCBI Gene:5330 PLCB2

OMIM:604114 PLCB2

UCSC:Q00722 PLCB2

Reference Transcript

Other Identifiers

11722131_a_at

11750570_x_at

11754492_x_at

11759840_at

16807342

204046_PM_at

204046_at

210388_PM_at

210388_at

210_at

3619314

3619327

3619329

3619330

3619331

3619332

3619333

3619334

3619335

3619336

3619337

3619338

3619340

3619341

3619342

3619343

3619344

3619345

3619346

3619347

3619348

3619349

3619350

3619351

3619352

3619353

3619354

3619356

3619357

3619359

3619360

3619361

3619362

3619363

3619364

3619365

3619366

3619367

3619368

3619369

3619370

3619371

3619372

3619373

3619374

3619375

3619376

3619377

3619379

3619380

3619381

3619382

3619383

3619384

3619385

3619387

3619388

5330

7987475

A_24_P287664

A_24_P936779

A_33_P3260614

GE81412

GO:0001580

GO:0003824

GO:0004435

GO:0004629

GO:0005509

GO:0005515

GO:0005543

GO:0005737

GO:0005829

GO:0006629

GO:0006644

GO:0007165

GO:0007186

GO:0007200

GO:0008081

GO:0008289

GO:0016042

GO:0016787

GO:0031410

GO:0031680

GO:0031683

GO:0035556

GO:0043226

GO:0046488

GO:0046872

GO:0048015

GO:0050877

GO:0050913

GO:0051209

GO:0055085

GO:0098992

HMNXSV003026215

HMNXSV003030001

HMNXSV003051126

ILMN_1724066

M95678_at

PH_hs_0017247

TC15001233.hg

g12803010_3p_at

g12803010_3p_x_at

g4758937_3p_at

Participates

as a candidate of

PLC beta1,2,3 [cytosol] (Homo sapiens)

as a member of

as a component of

PLCB2:Ca2+ [cytosol] (Homo sapiens)

Inferred To

PLCB2 [cytosol] (Bos taurus)

PLCB2 [cytosol] (Canis familiaris)

PLCB2 [cytosol] (Dictyostelium discoideum)

PLCB2 [cytosol] (Drosophila melanogaster)

PLCB2 [cytosol] (Gallus gallus)

PLCB2 [cytosol] (Mus musculus)

PLCB2 [cytosol] (Plasmodium falciparum)

PLCB2 [cytosol] (Rattus norvegicus)

PLCB2 [cytosol] (Saccharomyces cerevisiae)

PLCB2 [cytosol] (Schizosaccharomyces pombe)

PLCB2 [cytosol] (Sus scrofa)

PLCB2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_004564.2, NP_001271227.1, NP_001271226.1

Guide to Pharmacology - Targets

1404

ENSEMBL

ENSP00000453975, ENSP00000411991, ENST00000557821, ENST00000456256, ENSP00000260402, ENSG00000137841, ENST00000260402

OpenTargets

ENSG00000137841

IntEnz

3.1.4.11

GeneCards

PLCB2

HPA

ENSG00000137841-PLCB2

PRO

Q00722

Pharos - Targets

Q00722

HMDB Protein

HMDBP00224

PDB

2ZKM, 2FJU

Cite Us!