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PTGS2 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-61605
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Prostaglandin G/H synthase 2 precursor , Cyclooxygenase -2, COX-2, Prostaglandin-endoperoxide synthase 2, Prostaglandin H2 synthase 2, PGH synthase 2, PGHS-2, PHS II
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-10 signaling (Homo sapiens)
Expression of PTGS2 (Homo sapiens)
PTGS2 [endoplasmic reticulum membrane] (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of PTGS2 (Homo sapiens)
PTGS2 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Biosynthesis of specialized proresolving mediators (SPMs) (Homo sapiens)
Biosynthesis of DHA-derived SPMs (Homo sapiens)
Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Homo sapiens)
Ac-PTGS2 dimer [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 [endoplasmic reticulum membrane] (Homo sapiens)
Biosynthesis of DPA-derived SPMs (Homo sapiens)
Biosynthesis of DPAn-3 SPMs (Homo sapiens)
PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Homo sapiens)
PTGS2 dimer [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 [endoplasmic reticulum membrane] (Homo sapiens)
Biosynthesis of EPA-derived SPMs (Homo sapiens)
Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Homo sapiens)
Ac-PTGS2 dimer [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 [endoplasmic reticulum membrane] (Homo sapiens)
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives (Homo sapiens)
Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Homo sapiens)
Ac-PTGS2 dimer [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 [endoplasmic reticulum membrane] (Homo sapiens)
Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Homo sapiens)
Ac-PTGS2 dimer [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 dimer oxidises DHA to 13-HDHA (Homo sapiens)
PTGS2 dimer [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 dimer oxidises EPA to PGH3 (Homo sapiens)
PTGS2 dimer [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 [endoplasmic reticulum membrane] (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonic acid metabolism (Homo sapiens)
Synthesis of 15-eicosatetraenoic acid derivatives (Homo sapiens)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Homo sapiens)
Ac-PTGS2 dimer [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 [endoplasmic reticulum membrane] (Homo sapiens)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Homo sapiens)
ASA- acetylates PTGS2 (Homo sapiens)
Ac-PTGS2 dimer [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 dimer [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 [endoplasmic reticulum membrane] (Homo sapiens)
Arachidonic acid is oxidised to PGG2 by PTGS2 (Homo sapiens)
PTGS2 dimer [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 [endoplasmic reticulum membrane] (Homo sapiens)
PGG2 is reduced to PGH2 by PTGS2 (Homo sapiens)
PTGS2 dimer [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 dimer:PTGS2 inhibitors [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 dimer [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 dimer binds PTGS2 inhibitors (Homo sapiens)
PTGS2 dimer [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 dimer:PTGS2 inhibitors [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 dimer [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Nicotinate metabolism (Homo sapiens)
Nicotinamide salvaging (Homo sapiens)
PGG2 is reduced to PGH2 by PTGS2 (Homo sapiens)
PTGS2 dimer [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 dimer:PTGS2 inhibitors [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 dimer [endoplasmic reticulum membrane] (Homo sapiens)
PTGS2 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35354 PTGS2
Gene Names
PTGS2, COX2
Chain
signal peptide:1-17, chain:18-604
Reference Genes
BioGPS Gene:5743 PTGS2
COSMIC (genes):PTGS2 PTGS2
CTD Gene:5743 PTGS2
dbSNP Gene:5743 PTGS2
ENSEMBL:ENSG00000073756 PTGS2
ENSEMBL:ENSG00000073756.13 PTGS2
HGNC:9605 PTGS2
KEGG Gene (Homo sapiens):5743 PTGS2
Monarch:5743 PTGS2
NCBI Gene:5743 PTGS2
OMIM:600262 PTGS2
UCSC:P35354 PTGS2
Reference Transcript
RefSeq:NM_000963.3 PTGS2
Other Identifiers
1069_at
11724036_a_at
11724037_at
11724038_a_at
1554997_PM_a_at
1554997_a_at
16697370
204748_PM_at
204748_at
2448383
2448384
2448385
2448386
2448387
2448389
2448391
2448394
2448395
2448396
2448397
2448398
2448399
2448400
2448401
2448402
2448403
5743
7922976
A_24_P250922
A_24_P77008
D28235_s_at
GE62312
GO:0001516
GO:0001525
GO:0003012
GO:0003013
GO:0003824
GO:0004601
GO:0004666
GO:0005515
GO:0005634
GO:0005635
GO:0005637
GO:0005640
GO:0005737
GO:0005783
GO:0005788
GO:0005789
GO:0005886
GO:0005901
GO:0006629
GO:0006631
GO:0006633
GO:0006693
GO:0006886
GO:0006913
GO:0006954
GO:0006979
GO:0007566
GO:0007612
GO:0007613
GO:0008217
GO:0008284
GO:0008285
GO:0009410
GO:0009624
GO:0009750
GO:0010033
GO:0010042
GO:0010243
GO:0010575
GO:0012501
GO:0014070
GO:0016020
GO:0016209
GO:0016491
GO:0016702
GO:0019371
GO:0019899
GO:0020037
GO:0022414
GO:0023052
GO:0030154
GO:0030282
GO:0031394
GO:0031622
GO:0031915
GO:0032227
GO:0032310
GO:0032355
GO:0032496
GO:0032991
GO:0033138
GO:0033280
GO:0034097
GO:0034605
GO:0034612
GO:0035633
GO:0036211
GO:0042127
GO:0042307
GO:0042633
GO:0042803
GO:0043005
GO:0043065
GO:0043066
GO:0043154
GO:0043226
GO:0043231
GO:0045429
GO:0045786
GO:0045907
GO:0045986
GO:0045987
GO:0046697
GO:0046872
GO:0048661
GO:0048856
GO:0048870
GO:0050727
GO:0050873
GO:0050877
GO:0051213
GO:0051384
GO:0051926
GO:0051968
GO:0070542
GO:0071260
GO:0071284
GO:0071318
GO:0071417
GO:0071456
GO:0071471
GO:0071498
GO:0071636
GO:0071704
GO:0090050
GO:0090271
GO:0090336
GO:0090362
GO:0098754
GO:0098869
GO:0150077
GO:1902219
GO:1990776
HMNXSV003013175
Hs2.196384.2.S1_3p_s_at
ILMN_1677511
ILMN_2054297
L15326_s_at
PH_hs_0011595
TC01003638.hg
U04636_rna1_at
g4506264_3p_at
g4506264_3p_x_at
Participates
as an output of
Expression of PTGS2 (Homo sapiens)
as a component of
PTGS2 dimer [endoplasmic reticulum membrane] (Homo sapiens)
Ac-PTGS2 dimer [endoplasmic reticulum membrane] (Homo sapiens)
Other forms of this molecule
O-acetyl-L-serine-PTGS2 [endoplasmic reticulum membrane]
Inferred To
PTGS2 [endoplasmic reticulum membrane]
(Bos taurus)
PTGS2 [endoplasmic reticulum membrane]
(Canis familiaris)
PTGS2 [endoplasmic reticulum membrane]
(Danio rerio)
PTGS2 [endoplasmic reticulum membrane]
(Gallus gallus)
PTGS2 [endoplasmic reticulum membrane]
(Mus musculus)
PTGS2 [endoplasmic reticulum membrane]
(Rattus norvegicus)
PTGS2 [endoplasmic reticulum membrane]
(Sus scrofa)
PTGS2 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_000954.1
ZINC - World Drugs
PGH2_HUMAN
Guide to Pharmacology - Targets
1376
OpenTargets
ENSG00000073756
ZINC - FDA approved
PGH2_HUMAN
ZINC - Substances
PGH2_HUMAN
ZINC - Biogenic
PGH2_HUMAN
ZINC target
P35354
PRO
P35354
PDB
5IKV
,
5IKT
,
5IKQ
,
5KIR
,
5F19
,
5IKR
,
5F1A
ZINC - Investigational
PGH2_HUMAN
ZINC - Metabolites
PGH2_HUMAN
GeneCards
P35354
HPA
ENSG00000073756-PTGS2
Ensembl
ENST00000367468
,
ENSP00000506242
,
ENSP00000356438
,
ENST00000680451
,
ENSG00000073756
Pharos - Targets
P35354
Orphanet
24833
ZINC - Predictions - Purchasable
PGH2_HUMAN
HMDB Protein
HMDBP00975
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q86V38 Q86V38
0.556
3
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