Expression of PTGS2

Stable Identifier
R-HSA-6790029
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, nucleoplasm
ReviewStatus
5/5
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Expression of PTGS2
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Signal transducer and activator of transcription 3 (STAT3) is a key regulator of gene expression in response to signaling of many cytokines including interleukin-6 (IL6), Oncostatin M, and leukemia inhibitory factor. Using microarray techniques, hundreds of genes have been reported as potential STAT3 target genes (Dauer et al. 2005, Hsieh et al. 2005). Some of these genes have been proven to be direct STAT3 targets using genome-wide chromatin immunoprecipitation screening (Snyder et al. 2008, Carpenter & Lo 2014), including the gene which encodes the endoplasmic reticulum membrane protein Prostaglandin G/H synthase 2 (PTGS2, COX2) (Lo et al. 2010).
Literature References
PubMed ID Title Journal Year
20145033 Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes

Zhu, H, Lo, HW, Ali-Osman, F, Cao, X

Mol. Cancer Res. 2010
24743777 STAT3 Target Genes Relevant to Human Cancers

Lo, HW, Carpenter, RL

Cancers (Basel) 2014
Participants
Input
Output
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as an event of
This event is regulated
Positively by
Regulator
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
Authored
Jupe, S  (2015-07-01)
Reviewed
Leibovich, SJ  (2016-09-02)
Created
Jupe, S  (2015-08-06)
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