Reactome | PRKCG [cytosol]

PRKCG [cytosol]

Stable Identifier

R-HSA-58204

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein kinase C, gamma type , PKC-gamma

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Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Glutamate binding, activation of AMPA receptors and synaptic plasticity (Homo sapiens)
      - Trafficking of AMPA receptors (Homo sapiens)
        
        Trafficking of GluR2-containing AMPA receptors (Homo sapiens)
        
        Endocytosis of Ca impermeable AMPA receptors (Homo sapiens)
        
        Activated conventional protein kinase C [plasma membrane] (Homo sapiens)
        
        Activated PKC gamma [plasma membrane] (Homo sapiens)
        
        PRKCG [cytosol] (Homo sapiens)
        
        Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Homo sapiens)
        
        Activated conventional protein kinase C [plasma membrane] (Homo sapiens)
        
        Activated PKC gamma [plasma membrane] (Homo sapiens)
        
        PRKCG [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        GRK2 binds CALM1:4Ca2+ (Homo sapiens)
        
        active PKC (alpha, gamma, delta) [cytosol] (Homo sapiens)
        
        Protein kinase C (alpha, gamma, delta) [cytosol] (Homo sapiens)
        
        PRKCG [cytosol] (Homo sapiens)
        
        PKC phosphorylates GRK2 (Homo sapiens)
        
        active PKC (alpha, gamma, delta) [cytosol] (Homo sapiens)
        
        Protein kinase C (alpha, gamma, delta) [cytosol] (Homo sapiens)
        
        PRKCG [cytosol] (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        GRK2 binds CALM1:4Ca2+ (Homo sapiens)
        
        active PKC (alpha, gamma, delta) [cytosol] (Homo sapiens)
        
        Protein kinase C (alpha, gamma, delta) [cytosol] (Homo sapiens)
        
        PRKCG [cytosol] (Homo sapiens)
        
        PKC phosphorylates GRK2 (Homo sapiens)
        
        active PKC (alpha, gamma, delta) [cytosol] (Homo sapiens)
        
        Protein kinase C (alpha, gamma, delta) [cytosol] (Homo sapiens)
        
        PRKCG [cytosol] (Homo sapiens)
    - G alpha (z) signalling events (Homo sapiens)
      - G-alpha(z):PKC dissociates to give phosphorylated G alpha (z) (Homo sapiens)
        
        Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
        
        Activated conventional protein kinase C [plasma membrane] (Homo sapiens)
        
        Activated PKC gamma [plasma membrane] (Homo sapiens)
        
        PRKCG [cytosol] (Homo sapiens)
        
        p(S27)-G-alpha(z):GTP:PKC [plasma membrane] (Homo sapiens)
        
        Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
        
        Activated conventional protein kinase C [plasma membrane] (Homo sapiens)
        
        Activated PKC gamma [plasma membrane] (Homo sapiens)
        
        PRKCG [cytosol] (Homo sapiens)
      - PKC binds active G alpha (z) (Homo sapiens)
        
        G-alpha(z):GTP:PKC [plasma membrane] (Homo sapiens)
        
        Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
        
        Activated conventional protein kinase C [plasma membrane] (Homo sapiens)
        
        Activated PKC gamma [plasma membrane] (Homo sapiens)
        
        PRKCG [cytosol] (Homo sapiens)
        
        Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
        
        Activated conventional protein kinase C [plasma membrane] (Homo sapiens)
        
        Activated PKC gamma [plasma membrane] (Homo sapiens)
        
        PRKCG [cytosol] (Homo sapiens)
      - PKC phosphorylates G alpha (z) (Homo sapiens)
        
        G-alpha(z):GTP:PKC [plasma membrane] (Homo sapiens)
        
        Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
        
        Activated conventional protein kinase C [plasma membrane] (Homo sapiens)
        
        Activated PKC gamma [plasma membrane] (Homo sapiens)
        
        PRKCG [cytosol] (Homo sapiens)
        
        Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
        
        Activated conventional protein kinase C [plasma membrane] (Homo sapiens)
        
        Activated PKC gamma [plasma membrane] (Homo sapiens)
        
        PRKCG [cytosol] (Homo sapiens)
        
        p(S27)-G-alpha(z):GTP:PKC [plasma membrane] (Homo sapiens)
        
        Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
        
        Activated conventional protein kinase C [plasma membrane] (Homo sapiens)
        
        Activated PKC gamma [plasma membrane] (Homo sapiens)
        
        PRKCG [cytosol] (Homo sapiens)
- Signaling by WNT (Homo sapiens)
  - Beta-catenin independent WNT signaling (Homo sapiens)
    - PCP/CE pathway (Homo sapiens)
      - WNT5A-dependent internalization of FZD4 (Homo sapiens)
        
        DVL2 is phosphorylated by PKC (Homo sapiens)
        
        Activated Protein kinase C (alpha, beta, gamma isoforms) [plasma membrane] (Homo sapiens)
        
        Activated PKC gamma [plasma membrane] (Homo sapiens)
        
        PRKCG [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P05129 PRKCG

Gene Names

PRKCG, PKCG

Chain

chain:1-697

Reference Genes

BioGPS Gene:5582 PRKCG

COSMIC (genes):PRKCG PRKCG

CTD Gene:5582 PRKCG

dbSNP Gene:5582 PRKCG

ENSEMBL:ENSG00000126583 PRKCG

ENSEMBL_homo_sapiens_GENE:ENSG00000126583.12 PRKCG

HGNC:9402 PRKCG

KEGG Gene (Homo sapiens):5582 PRKCG

Monarch:5582 PRKCG

NCBI Gene:5582 PRKCG

OMIM:176980 PRKCG

UCSC:P05129 PRKCG

Reference Transcript

Other Identifiers

11729115_a_at

11729116_at

11729117_a_at

11752941_a_at

16865128

206270_PM_at

206270_at

236195_PM_x_at

236195_x_at

363_at

3841103

3841104

3841105

3841106

3841107

3841108

3841109

3841110

3841111

3841112

3841113

3841114

3841115

3841116

3841117

3841118

3841119

3841121

3841122

3841123

3841124

3841126

3841127

3841128

3841129

3841130

3841131

48335_at

5582

8031057

A_23_P16189

GE60357

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0004697

GO:0004698

GO:0004712

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0005911

GO:0006281

GO:0006468

GO:0007268

GO:0007611

GO:0007635

GO:0008270

GO:0009636

GO:0012501

GO:0014069

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0030163

GO:0030425

GO:0031397

GO:0032095

GO:0032425

GO:0035556

GO:0036211

GO:0042177

GO:0042752

GO:0042995

GO:0043005

GO:0043226

GO:0043278

GO:0043524

GO:0044305

GO:0045202

GO:0046872

GO:0048265

GO:0048471

GO:0048511

GO:0048856

GO:0050764

GO:0050877

GO:0060291

GO:0060384

GO:0080090

GO:0097060

GO:0099171

GO:0099523

GO:0099524

GO:0106310

GO:0140096

GO:1901799

GO:1990911

GO:2000300

HMNXSV003056805

Hs.90037.0.A1_3p_at

ILMN_1739812

PH_hs_0000366

TC19000866.hg

Z15114_at

g13384593_3p_at

Participates

as a member of

as a component of

Activated PKC gamma [plasma membrane] (Homo sapiens)

Inferred To

PRKCG [cytosol] (Caenorhabditis elegans)

PRKCG [cytosol] (Canis familiaris)

PRKCG [cytosol] (Dictyostelium discoideum)

PRKCG [cytosol] (Drosophila melanogaster)

PRKCG [cytosol] (Mus musculus)

PRKCG [cytosol] (Rattus norvegicus)

PRKCG [cytosol] (Saccharomyces cerevisiae)

PRKCG [cytosol] (Schizosaccharomyces pombe)

PRKCG [cytosol] (Sus scrofa)

PRKCG [cytosol] (Xenopus tropicalis)

Homologues of PRKCG [cytosol] (Dictyostelium discoideum)

Homologues of PRKCG [cytosol] (Drosophila melanogaster)

Homologues of PRKCG [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001303258.1, NP_002730.1

Guide to Pharmacology - Targets

1484

OpenTargets

ENSG00000126583

ZINC - Substances

KPCG_HUMAN

ZINC target

P05129

ZINC - Biogenic

KPCG_HUMAN

PRO

P05129

PDB

2E73, 2UZP

ZINC - Investigational

KPCG_HUMAN

HPA

ENSG00000126583-PRKCG

GeneCards

P05129

Ensembl

ENSG00000126583, ENST00000263431, ENSP00000263431

Pharos - Targets

P05129

Orphanet

15140

ZINC - Predictions - Purchasable

KPCG_HUMAN

HMDB Protein

HMDBP01479

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P17252 PRKCA	8	PRKCA [cytosol] (R-HSA-58196) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) PRKCA [plasma membrane] (R-HSA-156469) p-T497-PRKCA [cytosol] (R-HSA-5218731) p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292) PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [nucleoplasm] (R-HSA-450530)	0.643	4
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.564	2
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.556	3

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