Protein Kinase C, conventional

Stable Identifier
R-HSA-114528
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

These PKC isoforms are activated by PS in a Ca2+-dependent manner; they also bind DAG, which both increases the specificity of the enzyme for PS and also shifts the affinity for Ca2+ into the physiological range. They are targets of the tumour-promoting phorbol ester PMA, which activates these enzymes by eliminating the requirement for DAG and decreasing the concentration of Ca2+ needed for activation.

Participants
Participant Of
Inferred To