Reactome | PRKCG [cytosol]

PRKCG [cytosol]

Stable Identifier

R-MMU-58204

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

P63318

Locations in the PathwayBrowser

Expand all

Neuronal System (Mus musculus)

- Transmission across Chemical Synapses (Mus musculus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Mus musculus)
    - Glutamate binding, activation of AMPA receptors and synaptic plasticity (Mus musculus)
      - Trafficking of AMPA receptors (Mus musculus)
        
        Trafficking of GluR2-containing AMPA receptors (Mus musculus)
        
        Endocytosis of Ca impermeable AMPA receptors (Mus musculus)
        
        Activated conventional protein kinase C [plasma membrane] (Mus musculus)
        
        Activated PKC gamma [plasma membrane] (Mus musculus)
        
        PRKCG [cytosol] (Mus musculus)
        
        Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Mus musculus)
        
        Activated conventional protein kinase C [plasma membrane] (Mus musculus)
        
        Activated PKC gamma [plasma membrane] (Mus musculus)
        
        PRKCG [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - DAG and IP3 signaling (Mus musculus)
    - CaM pathway (Mus musculus)
      - Calmodulin induced events (Mus musculus)
        
        GRK2 binds CALM1:4Ca2+ (Mus musculus)
        
        active PKC (alpha, gamma, delta) [cytosol] (Mus musculus)
        
        Protein kinase C (alpha, gamma, delta) [cytosol] (Mus musculus)
        
        PRKCG [cytosol] (Mus musculus)
        
        PKC phosphorylates GRK2 (Mus musculus)
        
        active PKC (alpha, gamma, delta) [cytosol] (Mus musculus)
        
        Protein kinase C (alpha, gamma, delta) [cytosol] (Mus musculus)
        
        PRKCG [cytosol] (Mus musculus)
- Signaling by GPCR (Mus musculus)
  - GPCR downstream signalling (Mus musculus)
    - G alpha (i) signalling events (Mus musculus)
      - Opioid Signalling (Mus musculus)
        
        G-protein mediated events (Mus musculus)
        
        PLC beta mediated events (Mus musculus)
        
        Ca-dependent events (Mus musculus)
        
        CaM pathway (Mus musculus)
        
        Calmodulin induced events (Mus musculus)
        
        GRK2 binds CALM1:4Ca2+ (Mus musculus)
        
        active PKC (alpha, gamma, delta) [cytosol] (Mus musculus)
        
        Protein kinase C (alpha, gamma, delta) [cytosol] (Mus musculus)
        
        PRKCG [cytosol] (Mus musculus)
        
        PKC phosphorylates GRK2 (Mus musculus)
        
        active PKC (alpha, gamma, delta) [cytosol] (Mus musculus)
        
        Protein kinase C (alpha, gamma, delta) [cytosol] (Mus musculus)
        
        PRKCG [cytosol] (Mus musculus)
- Signaling by WNT (Mus musculus)
  - Beta-catenin independent WNT signaling (Mus musculus)
    - PCP/CE pathway (Mus musculus)
      - WNT5A-dependent internalization of FZD4 (Mus musculus)
        
        DVL2 is phosphorylated by PKC (Mus musculus)
        
        Activated Protein kinase C (alpha, beta, gamma isoforms) [plasma membrane] (Mus musculus)
        
        Activated PKC gamma [plasma membrane] (Mus musculus)
        
        PRKCG [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P63318

Reference Genes

BioGPS Gene:18752

ENSEMBL:ENSMUSG00000078816

ENSEMBL:ENSMUSG00000078816.11

KEGG Gene (Mus musculus):18752

Monarch:18752

NCBI Gene:18752

UCSC:P63318

Reference Transcript

RefSeq:NM_011102.4

Other Identifiers

10608705

1421446_at

1455758_at

17473135

18752

93648_at

A_51_P290290

A_55_P1976282

A_66_P126414

GE35901

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0004697

GO:0004698

GO:0004712

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0005911

GO:0006281

GO:0006468

GO:0007268

GO:0007611

GO:0007635

GO:0008270

GO:0009636

GO:0012501

GO:0014069

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0030163

GO:0030425

GO:0031397

GO:0032095

GO:0032425

GO:0035556

GO:0036211

GO:0042177

GO:0042221

GO:0042752

GO:0042995

GO:0043005

GO:0043226

GO:0043278

GO:0043524

GO:0044305

GO:0045202

GO:0046872

GO:0048265

GO:0048471

GO:0048511

GO:0048856

GO:0050764

GO:0050877

GO:0060291

GO:0060384

GO:0097060

GO:0099171

GO:0099523

GO:0099524

GO:0106310

GO:0140096

GO:1901799

GO:1990911

GO:2000300

ILMN_2598430

Msa.1082.0_at

mMR029131

Participates

as a member of

as a component of

Activated PKC gamma [plasma membrane] (Mus musculus)

Inferred From

PRKCG [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_035232.1

Ensembl

ENSMUST00000100301, ENSMUSG00000078816, ENSMUSP00000097874

PRO

P63318

MGI

97597

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35438 Grin1	3	Grin1 [plasma membrane] (R-MMU-3928395) Grin1 [endoplasmic reticulum membrane] (R-MMU-9610359) Grin1 [transport vesicle membrane] (R-MMU-9610566)	0.462	2

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