Ligation of newly synthesized repair patch to incised DNA in GG-NER

Stable Identifier
R-HSA-5690997
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Ligation of newly synthesized repair patch to incised DNA in GG-NER
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The nucleotide excision repair (NER) is completed when the newly synthesized fragment is ligated to the incised DNA strand, thus closing the single stranded nick (SSB). Two DNA ligases, LIG1 and LIG3, can perform the ligation in global genome NER (GG-NER), as well as in transcription-coupled NER (TC-NER) (Arakawa et al. 2012, Paul-Konietzko et al. 2015).
Literature References
PubMed ID Title Journal Year
26131740 DNA Ligases I and III Support Nucleotide Excision Repair in DT40 Cells with Similar Efficiency

Paul-Konietzko, K, Thomale, J, Arakawa, H, Iliakis, G

Photochem Photobiol 2015
22127868 Functional redundancy between DNA ligases I and III in DNA replication in vertebrate cells

Arakawa, H, Bednar, T, Wang, M, Paul, K, Mladenov, E, Bencsik-Theilen, AA, Iliakis, G

Nucleic Acids Res 2012
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Catalyst Activity

DNA ligase activity of LIG1,LIG3:XRCC1 [nucleoplasm]

Physical Entity
LIG1,LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
Activity
DNA ligase activity (GO:0003909)
Authored
Gopinathrao, G  (2004-02-02)
Hoeijmakers, JH  (2004-01-29)
Orlic-Milacic, M  (2015-06-16)
Reviewed
Fousteri, M  (2015-08-03)
Created
Orlic-Milacic, M  (2015-05-04)
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