The nucleotide excision repair (NER) is completed when the newly synthesized fragment is ligated to the incised DNA strand, thus closing the single stranded nick (SSB). Two DNA ligases, LIG1 and LIG3 (as part of the LIG3:XRCC1 complex) can perform the ligation in global genome NER (GG-NER), as well as in transcription-coupled NER (TC-NER). The choice of NER DNA ligase depends on the DNA polymerase involved in the repair synthesis and on the stage of the cell cycle (Moser et al. 2007).
Fousteri, M, Mullenders, LH, Giakzidis, I, Moser, J, Caldecott, K, Kool, H
DNA ligase activity of LIG1,LIG3:XRCC1 [nucleoplasm]
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