Gap-filling DNA repair synthesis and ligation in GG-NER

Stable Identifier
R-HSA-5696397
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Gap-filling DNA repair synthesis and ligation in GG-NER
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Global genome nucleotide excision repair (GG-NER) is completed by DNA repair synthesis that fills the single stranded gap created after dual incision of the damaged DNA strand and excision of the ~27-30 bases long oligonucleotide that contains the lesion. DNA synthesis is performed by DNA polymerases epsilon or delta, or the Y family DNA polymerase kappa (POLK), which are loaded to the repair site after 5' incision (Staresincic et al. 2009, Ogi et al. 2010). DNA ligases LIG1 or LIG3 ligate the newly synthesized stretch of oligonucleotides to the incised DNA strand (Arakawa et al. 2012, Paul-Konietzko et al. 2015).
Literature References
PubMed ID Title Journal Year
20227374 Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells

Ogi, T, Limsirichaikul, S, Overmeer, RM, Volker, M, Takenaka, K, Cloney, R, Nakazawa, Y, Niimi, A, Miki, Y, Jaspers, NG, Mullenders, LH, Yamashita, S, Fousteri, M, Lehmann, AR

Mol. Cell 2010
26131740 DNA Ligases I and III Support Nucleotide Excision Repair in DT40 Cells with Similar Efficiency

Paul-Konietzko, K, Thomale, J, Arakawa, H, Iliakis, G

Photochem Photobiol 2015
22127868 Functional redundancy between DNA ligases I and III in DNA replication in vertebrate cells

Arakawa, H, Bednar, T, Wang, M, Paul, K, Mladenov, E, Bencsik-Theilen, AA, Iliakis, G

Nucleic Acids Res 2012
19279666 Coordination of dual incision and repair synthesis in human nucleotide excision repair

Staresincic, L, Fagbemi, AF, Enzlin, JH, Gourdin, AM, Wijgers, N, Dunand-Sauthier, I, Giglia-Mari, G, Clarkson, SG, Vermeulen, W, Schärer, OD

EMBO J. 2009
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
nucleotide-excision repair, DNA gap filling (0006297)
Orthologous Events
Gap-filling DNA repair synthesis and ligation in GG-NER (Bos taurus)
Gap-filling DNA repair synthesis and ligation in GG-NER (Caenorhabditis elegans)
Gap-filling DNA repair synthesis and ligation in GG-NER (Canis familiaris)
Gap-filling DNA repair synthesis and ligation in GG-NER (Danio rerio)
Gap-filling DNA repair synthesis and ligation in GG-NER (Drosophila melanogaster)
Gap-filling DNA repair synthesis and ligation in GG-NER (Gallus gallus)
Gap-filling DNA repair synthesis and ligation in GG-NER (Mus musculus)
Gap-filling DNA repair synthesis and ligation in GG-NER (Rattus norvegicus)
Gap-filling DNA repair synthesis and ligation in GG-NER (Schizosaccharomyces pombe)
Gap-filling DNA repair synthesis and ligation in GG-NER (Sus scrofa)
Cross References
BioModels Database
Authored
Gopinathrao, G  (2004-02-02)
Hoeijmakers, JH  (2004-01-29)
Orlic-Milacic, M  (2015-06-16)
Reviewed
Fousteri, M  (2015-08-03)
Created
Orlic-Milacic, M  (2015-05-28)
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