p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol

Stable Identifier
Reaction [omitted]
Homo sapiens
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Binding of MAPK6 or 4 to MAPKAPK5 promotes its redistribution to the cytosol. This depends on a functional protein-protein interaction interface between the two proteins. Cytoplasmic translocation of MAPKAPK5 occurs even in the presence of catalytically inactive MAPK6 or MAPK6 and vice versa, MAPK6 and MAPK4 still provoke nuclear exclusion of kinase inactive MAPKAPK5 (Aberg et al, 2006; Seternes et al, 2004; Kant et al, 2006; reviewed in Kostenko et al, 2012). Phosphorylation of MAPK6 or MAPK4 at S189 or S186 respectively, is required for binding and translocation of MAPKAPK5 to the cytosol (Perander et al, 2008; Deleris et al, 2008; De La Mota-Peynado et al, 2011).
Literature References
PubMed ID Title Journal Year
22800433 Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5

Dumitriu, G, Kostenko, S, Moens, U

J Mol Signal 2012
16973613 Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5

Kispert, A, Schumacher, S, Kant, S, Kotlyarov, A, Singh, MK, Gaestel, M

J. Biol. Chem. 2006
16971392 Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4

Meloche, S, Julien, C, Johansen, B, Aberg, E, Keyse, SM, Perander, M, Seternes, OM

J. Biol. Chem. 2006
21317288 Identification of the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity

De la Mota-Peynado, A, Beeser, A, Chernoff, J

J. Biol. Chem. 2011
18720373 Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5

Déléris, P, Rousseau, J, Meloche, S, Rodier, G, Coulombe, P, Tanguay, PL

J. Cell. Physiol. 2008
15577943 Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway

Meloche, S, Johansen, B, Morrice, NA, Mikalsen, T, Moens, U, Armstrong, CG, Keyse, SM, Turgeon, B, Michaelsen, E, Seternes, OM

EMBO J. 2004
18248330 The Ser(186) phospho-acceptor site within ERK4 is essential for its ability to interact with and activate PRAK/MK5

Johansen, B, Aberg, E, Keyse, SM, Perander, M, Dreyer, B, Guldvik, IJ, Seternes, OM, Outzen, H

Biochem. J. 2008
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