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2'-O-acetyl-ADP-ribose [nucleoplasm]
Stable Identifier
R-ALL-427498
Type
Chemical Compound [SimpleEntity]
Compartment
nucleoplasm
Synonyms
2'-O-acetyl adenosine-5-diphosphoribose, 2''-O-acetyl-ADP-D-ribose
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to heat stress (Bos taurus)
Regulation of HSF1-mediated heat shock response (Bos taurus)
SIRT1 deacetylates HSF1 (Bos taurus)
2'-O-acetyl-ADP-ribose [nucleoplasm]
DNA Repair (Bos taurus)
DNA Double-Strand Break Repair (Bos taurus)
Homology Directed Repair (Bos taurus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Bos taurus)
Processing of DNA double-strand break ends (Bos taurus)
SIRT6 deacetylates RBBP8 (Bos taurus)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Developmental Biology (Bos taurus)
MITF-M-regulated melanocyte development (Bos taurus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Bos taurus)
SIRT1 deacetylates HINT1 dimer (Bos taurus)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Gene expression (Transcription) (Bos taurus)
Epigenetic regulation of gene expression (Bos taurus)
Negative epigenetic regulation of rRNA expression (Bos taurus)
SIRT1 negatively regulates rRNA expression (Bos taurus)
eNoSC deacetylates histone H3 (Bos taurus)
2'-O-acetyl-ADP-ribose [nucleoplasm]
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
FOXO-mediated transcription (Bos taurus)
Regulation of FOXO transcriptional activity by acetylation (Bos taurus)
SIRT1,SIRT3 deacetylate FOXO3 (Bos taurus)
2'-O-acetyl-ADP-ribose [nucleoplasm]
DNA Repair (Caenorhabditis elegans)
DNA Double-Strand Break Repair (Caenorhabditis elegans)
Homology Directed Repair (Caenorhabditis elegans)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Caenorhabditis elegans)
Processing of DNA double-strand break ends (Caenorhabditis elegans)
SIRT6 deacetylates RBBP8 (Caenorhabditis elegans)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Developmental Biology (Caenorhabditis elegans)
MITF-M-regulated melanocyte development (Caenorhabditis elegans)
Transcriptional and post-translational regulation of MITF-M expression and activity (Caenorhabditis elegans)
SIRT1 deacetylates HINT1 dimer (Caenorhabditis elegans)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
FOXO-mediated transcription (Caenorhabditis elegans)
Regulation of FOXO transcriptional activity by acetylation (Caenorhabditis elegans)
SIRT1,SIRT3 deacetylate FOXO3 (Caenorhabditis elegans)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to heat stress (Canis familiaris)
Regulation of HSF1-mediated heat shock response (Canis familiaris)
SIRT1 deacetylates HSF1 (Canis familiaris)
2'-O-acetyl-ADP-ribose [nucleoplasm]
DNA Repair (Canis familiaris)
DNA Double-Strand Break Repair (Canis familiaris)
Homology Directed Repair (Canis familiaris)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Canis familiaris)
Processing of DNA double-strand break ends (Canis familiaris)
SIRT6 deacetylates RBBP8 (Canis familiaris)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Developmental Biology (Canis familiaris)
MITF-M-regulated melanocyte development (Canis familiaris)
Transcriptional and post-translational regulation of MITF-M expression and activity (Canis familiaris)
SIRT1 deacetylates HINT1 dimer (Canis familiaris)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Gene expression (Transcription) (Canis familiaris)
Epigenetic regulation of gene expression (Canis familiaris)
Negative epigenetic regulation of rRNA expression (Canis familiaris)
SIRT1 negatively regulates rRNA expression (Canis familiaris)
eNoSC deacetylates histone H3 (Canis familiaris)
2'-O-acetyl-ADP-ribose [nucleoplasm]
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
FOXO-mediated transcription (Canis familiaris)
Regulation of FOXO transcriptional activity by acetylation (Canis familiaris)
SIRT1,SIRT3 deacetylate FOXO3 (Canis familiaris)
2'-O-acetyl-ADP-ribose [nucleoplasm]
DNA Repair (Danio rerio)
DNA Double-Strand Break Repair (Danio rerio)
Homology Directed Repair (Danio rerio)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Danio rerio)
Processing of DNA double-strand break ends (Danio rerio)
SIRT6 deacetylates RBBP8 (Danio rerio)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Developmental Biology (Dictyostelium discoideum)
MITF-M-regulated melanocyte development (Dictyostelium discoideum)
Transcriptional and post-translational regulation of MITF-M expression and activity (Dictyostelium discoideum)
SIRT1 deacetylates HINT1 dimer (Dictyostelium discoideum)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Gene expression (Transcription) (Dictyostelium discoideum)
Epigenetic regulation of gene expression (Dictyostelium discoideum)
Negative epigenetic regulation of rRNA expression (Dictyostelium discoideum)
SIRT1 negatively regulates rRNA expression (Dictyostelium discoideum)
eNoSC deacetylates histone H3 (Dictyostelium discoideum)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Developmental Biology (Drosophila melanogaster)
MITF-M-regulated melanocyte development (Drosophila melanogaster)
Transcriptional and post-translational regulation of MITF-M expression and activity (Drosophila melanogaster)
SIRT1 deacetylates HINT1 dimer (Drosophila melanogaster)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Gene expression (Transcription) (Drosophila melanogaster)
Epigenetic regulation of gene expression (Drosophila melanogaster)
Negative epigenetic regulation of rRNA expression (Drosophila melanogaster)
SIRT1 negatively regulates rRNA expression (Drosophila melanogaster)
eNoSC deacetylates histone H3 (Drosophila melanogaster)
2'-O-acetyl-ADP-ribose [nucleoplasm]
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
FOXO-mediated transcription (Drosophila melanogaster)
Regulation of FOXO transcriptional activity by acetylation (Drosophila melanogaster)
SIRT1,SIRT3 deacetylate FOXO3 (Drosophila melanogaster)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular response to heat stress (Gallus gallus)
Regulation of HSF1-mediated heat shock response (Gallus gallus)
SIRT1 deacetylates HSF1 (Gallus gallus)
2'-O-acetyl-ADP-ribose [nucleoplasm]
DNA Repair (Gallus gallus)
DNA Double-Strand Break Repair (Gallus gallus)
Homology Directed Repair (Gallus gallus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Gallus gallus)
Processing of DNA double-strand break ends (Gallus gallus)
SIRT6 deacetylates RBBP8 (Gallus gallus)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Developmental Biology (Gallus gallus)
MITF-M-regulated melanocyte development (Gallus gallus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Gallus gallus)
SIRT1 deacetylates HINT1 dimer (Gallus gallus)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Gene expression (Transcription) (Gallus gallus)
RNA Polymerase II Transcription (Gallus gallus)
Generic Transcription Pathway (Gallus gallus)
FOXO-mediated transcription (Gallus gallus)
Regulation of FOXO transcriptional activity by acetylation (Gallus gallus)
SIRT1,SIRT3 deacetylate FOXO3 (Gallus gallus)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to heat stress (Homo sapiens)
Regulation of HSF1-mediated heat shock response (Homo sapiens)
SIRT1 deacetylates HSF1 (Homo sapiens)
2'-O-acetyl-ADP-ribose [nucleoplasm]
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
Processing of DNA double-strand break ends (Homo sapiens)
SIRT6 deacetylates RBBP8 (Homo sapiens)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
Transcriptional and post-translational regulation of MITF-M expression and activity (Homo sapiens)
SIRT1 deacetylates HINT1 dimer (Homo sapiens)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Negative epigenetic regulation of rRNA expression (Homo sapiens)
SIRT1 negatively regulates rRNA expression (Homo sapiens)
SIRT1 deacetylates TAF1B in SL1 complex (Homo sapiens)
2'-O-acetyl-ADP-ribose [nucleoplasm]
eNoSC deacetylates histone H3 (Homo sapiens)
2'-O-acetyl-ADP-ribose [nucleoplasm]
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
Regulation of FOXO transcriptional activity by acetylation (Homo sapiens)
SIRT1 deacetylates FOXO1 (Homo sapiens)
2'-O-acetyl-ADP-ribose [nucleoplasm]
SIRT1,SIRT3 deacetylate FOXO3 (Homo sapiens)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Pre-NOTCH Expression and Processing (Homo sapiens)
Pre-NOTCH Transcription and Translation (Homo sapiens)
SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters (Homo sapiens)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to heat stress (Mus musculus)
Regulation of HSF1-mediated heat shock response (Mus musculus)
SIRT1 deacetylates HSF1 (Mus musculus)
2'-O-acetyl-ADP-ribose [nucleoplasm]
DNA Repair (Mus musculus)
DNA Double-Strand Break Repair (Mus musculus)
Homology Directed Repair (Mus musculus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Mus musculus)
Processing of DNA double-strand break ends (Mus musculus)
SIRT6 deacetylates RBBP8 (Mus musculus)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Developmental Biology (Mus musculus)
MITF-M-regulated melanocyte development (Mus musculus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Mus musculus)
SIRT1 deacetylates HINT1 dimer (Mus musculus)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
FOXO-mediated transcription (Mus musculus)
Regulation of FOXO transcriptional activity by acetylation (Mus musculus)
SIRT1,SIRT3 deacetylate FOXO3 (Mus musculus)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to heat stress (Rattus norvegicus)
Regulation of HSF1-mediated heat shock response (Rattus norvegicus)
SIRT1 deacetylates HSF1 (Rattus norvegicus)
2'-O-acetyl-ADP-ribose [nucleoplasm]
DNA Repair (Rattus norvegicus)
DNA Double-Strand Break Repair (Rattus norvegicus)
Homology Directed Repair (Rattus norvegicus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Rattus norvegicus)
Processing of DNA double-strand break ends (Rattus norvegicus)
SIRT6 deacetylates RBBP8 (Rattus norvegicus)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Developmental Biology (Rattus norvegicus)
MITF-M-regulated melanocyte development (Rattus norvegicus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Rattus norvegicus)
SIRT1 deacetylates HINT1 dimer (Rattus norvegicus)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Gene expression (Transcription) (Rattus norvegicus)
Epigenetic regulation of gene expression (Rattus norvegicus)
Negative epigenetic regulation of rRNA expression (Rattus norvegicus)
SIRT1 negatively regulates rRNA expression (Rattus norvegicus)
eNoSC deacetylates histone H3 (Rattus norvegicus)
2'-O-acetyl-ADP-ribose [nucleoplasm]
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
FOXO-mediated transcription (Rattus norvegicus)
Regulation of FOXO transcriptional activity by acetylation (Rattus norvegicus)
SIRT1,SIRT3 deacetylate FOXO3 (Rattus norvegicus)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Gene expression (Transcription) (Saccharomyces cerevisiae)
Epigenetic regulation of gene expression (Saccharomyces cerevisiae)
Negative epigenetic regulation of rRNA expression (Saccharomyces cerevisiae)
SIRT1 negatively regulates rRNA expression (Saccharomyces cerevisiae)
eNoSC deacetylates histone H3 (Saccharomyces cerevisiae)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Gene expression (Transcription) (Schizosaccharomyces pombe)
Epigenetic regulation of gene expression (Schizosaccharomyces pombe)
Negative epigenetic regulation of rRNA expression (Schizosaccharomyces pombe)
SIRT1 negatively regulates rRNA expression (Schizosaccharomyces pombe)
eNoSC deacetylates histone H3 (Schizosaccharomyces pombe)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Cellular responses to stimuli (Sus scrofa)
Cellular responses to stress (Sus scrofa)
Cellular response to heat stress (Sus scrofa)
Regulation of HSF1-mediated heat shock response (Sus scrofa)
SIRT1 deacetylates HSF1 (Sus scrofa)
2'-O-acetyl-ADP-ribose [nucleoplasm]
DNA Repair (Sus scrofa)
DNA Double-Strand Break Repair (Sus scrofa)
Homology Directed Repair (Sus scrofa)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Sus scrofa)
Processing of DNA double-strand break ends (Sus scrofa)
SIRT6 deacetylates RBBP8 (Sus scrofa)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Developmental Biology (Sus scrofa)
MITF-M-regulated melanocyte development (Sus scrofa)
Transcriptional and post-translational regulation of MITF-M expression and activity (Sus scrofa)
SIRT1 deacetylates HINT1 dimer (Sus scrofa)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Gene expression (Transcription) (Sus scrofa)
Epigenetic regulation of gene expression (Sus scrofa)
Negative epigenetic regulation of rRNA expression (Sus scrofa)
SIRT1 negatively regulates rRNA expression (Sus scrofa)
eNoSC deacetylates histone H3 (Sus scrofa)
2'-O-acetyl-ADP-ribose [nucleoplasm]
RNA Polymerase II Transcription (Sus scrofa)
Generic Transcription Pathway (Sus scrofa)
FOXO-mediated transcription (Sus scrofa)
Regulation of FOXO transcriptional activity by acetylation (Sus scrofa)
SIRT1,SIRT3 deacetylate FOXO3 (Sus scrofa)
2'-O-acetyl-ADP-ribose [nucleoplasm]
DNA Repair (Xenopus tropicalis)
DNA Double-Strand Break Repair (Xenopus tropicalis)
Homology Directed Repair (Xenopus tropicalis)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Xenopus tropicalis)
Processing of DNA double-strand break ends (Xenopus tropicalis)
SIRT6 deacetylates RBBP8 (Xenopus tropicalis)
2'-O-acetyl-ADP-ribose [nucleoplasm]
Literature References
PubMed ID
Title
Journal
Year
11893743
Structural identification of 2'- and 3'-O-acetyl-ADP-ribose as novel metabolites derived from the Sir2 family of beta -NAD+-dependent histone/protein deacetylases
Jackson, MD
,
Denu, JM
J Biol Chem
2002
External Reference Information
External Reference
2''-O-acetyl-ADP-D-ribose [ChEBI:76279]
Participates
as an output of
Sirt1 deacetylates Taf1b in SL1 complex (Mus musculus)
SIRT1 deacetylates TAF1B in SL1 complex (Homo sapiens)
eNoSC deacetylates histone H3 (Saccharomyces cerevisiae)
eNoSC deacetylates histone H3 (Schizosaccharomyces pombe)
eNoSC deacetylates histone H3 (Dictyostelium discoideum)
eNoSC deacetylates histone H3 (Drosophila melanogaster)
SIRT6 deacetylates RBBP8 (Mus musculus)
SIRT6 deacetylates RBBP8 (Homo sapiens)
SIRT6 deacetylates RBBP8 (Rattus norvegicus)
SIRT6 deacetylates RBBP8 (Canis familiaris)
SIRT6 deacetylates RBBP8 (Bos taurus)
SIRT6 deacetylates RBBP8 (Sus scrofa)
SIRT6 deacetylates RBBP8 (Danio rerio)
SIRT6 deacetylates RBBP8 (Xenopus tropicalis)
SIRT6 deacetylates RBBP8 (Gallus gallus)
SIRT6 deacetylates RBBP8 (Caenorhabditis elegans)
SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters (Homo sapiens)
Sirt6 deacetylates histones at Notch1 and Notch4 gene promoters (Mus musculus)
SIRT1 deacetylates FOXO1 (Homo sapiens)
Sirt1 deacetylates Foxo1 (Mus musculus)
SIRT1,SIRT3 deacetylate FOXO3 (Homo sapiens)
SIRT1,SIRT3 deacetylate FOXO3 (Mus musculus)
SIRT1,SIRT3 deacetylate FOXO3 (Rattus norvegicus)
SIRT1,SIRT3 deacetylate FOXO3 (Canis familiaris)
SIRT1,SIRT3 deacetylate FOXO3 (Bos taurus)
SIRT1,SIRT3 deacetylate FOXO3 (Sus scrofa)
SIRT1,SIRT3 deacetylate FOXO3 (Gallus gallus)
SIRT1,SIRT3 deacetylate FOXO3 (Drosophila melanogaster)
SIRT1,SIRT3 deacetylate FOXO3 (Caenorhabditis elegans)
SIRT1 deacetylates HSF1 (Homo sapiens)
SIRT1 deacetylates HSF1 (Mus musculus)
SIRT1 deacetylates HSF1 (Rattus norvegicus)
SIRT1 deacetylates HSF1 (Canis familiaris)
SIRT1 deacetylates HSF1 (Bos taurus)
SIRT1 deacetylates HSF1 (Sus scrofa)
SIRT1 deacetylates HSF1 (Gallus gallus)
SIRT1 deacetylates HINT1 dimer (Homo sapiens)
SIRT1 deacetylates HINT1 dimer (Mus musculus)
SIRT1 deacetylates HINT1 dimer (Rattus norvegicus)
SIRT1 deacetylates HINT1 dimer (Canis familiaris)
SIRT1 deacetylates HINT1 dimer (Bos taurus)
SIRT1 deacetylates HINT1 dimer (Sus scrofa)
SIRT1 deacetylates HINT1 dimer (Gallus gallus)
SIRT1 deacetylates HINT1 dimer (Drosophila melanogaster)
SIRT1 deacetylates HINT1 dimer (Caenorhabditis elegans)
SIRT1 deacetylates HINT1 dimer (Dictyostelium discoideum)
eNoSC deacetylates histone H3 (Homo sapiens)
eNoSC deacetylates histone H3 (Rattus norvegicus)
eNoSC deacetylates histone H3 (Canis familiaris)
eNoSC deacetylates histone H3 (Bos taurus)
eNoSC deacetylates histone H3 (Sus scrofa)
Other forms of this molecule
2'-O-acetyl-ADP-ribose [mitochondrial intermembrane space]
2'-O-acetyl-ADP-ribose [cytosol]
Cross References
Guide to Pharmacology - Ligands
6333
ZINC
000058638658
,
000096095472
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![2'-O-acetyl-ADP-ribose [nucleoplasm] icon](/icon/R-ICO-012356.svg){kind=icon}
