NR1D1 (REV-ERBA) binds heme, the ELOVL3 gene, and recruits corepressors

Stable Identifier
R-HSA-5663252
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NR1D1 (REV-ERBA) binds heme, the ELOVL3 gene, and recruits corepressors
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As inferred from mouse homologs, REV-ERBA (NR1D1) binds the promoter of the ELOVL3 gene and represses transcription, possibly by recruiting corepressors. ELOVL3 encodes very long chain fatty acid elongase-3 which catalyzes the rate-limiting step of the elongation of very long (C20-C24) fatty acid chains (inferred from the mouse homolog in Tvrdik et al. 2000). In male mice but not female mice, expression of Elvol3 is circadian and peaks diurnally (Brolinson et al. 2008).
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Inferred From
Nr1d1 (Rev-erba) binds heme, the Elovl3 gene, and recruits corepressors (Mus musculus)
Authored
May, B  (2015-01-16)
Reviewed
Delaunay, F  (2012-01-28)
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2015-01-17)
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