Reactome | NR1D1 [nucleoplasm]

NR1D1 [nucleoplasm]

Stable Identifier

R-HSA-375499

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

NR1D1_HUMAN, REV-ERB-alpha

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Organelle biogenesis and maintenance (Homo sapiens)

- Mitochondrial biogenesis (Homo sapiens)
  - Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
    - Expression of PPARGC1A (PGC-1alpha) (Homo sapiens)
      - NR1D1:heme:Corepressors:PPARGC1A gene [nucleoplasm] (Homo sapiens)
        
        NR1D1 (REV-ERBA):heme:Corepressor [nucleoplasm] (Homo sapiens)
        
        NR1D1 (REV-ERBA):heme [nucleoplasm] (Homo sapiens)
        
        NR1D1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P20393 NR1D1

Gene Names

NR1D1, EAR1, HREV, THRAL

Chain

chain:1-614

Reference Genes

BioGPS Gene:9572 NR1D1

COSMIC (genes):NR1D1 NR1D1

CTD Gene:9572 NR1D1

dbSNP Gene:9572 NR1D1

ENSEMBL:ENSG00000126368 NR1D1

HGNC:7962 NR1D1

KEGG:hsa:9572 NR1D1

Monarch:9572 NR1D1

NCBI Gene:9572 NR1D1

OMIM:602408 NR1D1

UCSC:P20393 NR1D1

Reference Transcript

RefSeq:NM_021724.4 NR1D1

Other Identifiers

11723989_s_at

16844294

204760_PM_s_at

204760_s_at

31637_3p_s_at

31637_PM_s_at

31637_s_at

3756052

3756053

3756057

3756059

3756060

3756061

3756062

3756063

3756064

3756065

3756066

3756072

3756073

3756074

3756075

3756076

3756077

3756078

4791857_3p_s_at

8014956

9572

A_23_P420873

A_24_P250227

GE79069

GO:0000122

GO:0000785

GO:0000976

GO:0000977

GO:0000978

GO:0000981

GO:0001222

GO:0001227

GO:0001678

GO:0003677

GO:0003700

GO:0003707

GO:0004879

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005975

GO:0005978

GO:0006091

GO:0006355

GO:0007623

GO:0008270

GO:0009755

GO:0010498

GO:0016604

GO:0019216

GO:0020037

GO:0030154

GO:0030163

GO:0030425

GO:0030522

GO:0031648

GO:0032922

GO:0034144

GO:0042632

GO:0042749

GO:0042752

GO:0042995

GO:0043124

GO:0043197

GO:0043226

GO:0043401

GO:0043565

GO:0044321

GO:0045202

GO:0045598

GO:0045892

GO:0045893

GO:0045944

GO:0046872

GO:0048511

GO:0050728

GO:0060086

GO:0060089

GO:0061178

GO:0061469

GO:0061889

GO:0070859

GO:0070888

GO:0071222

GO:0071347

GO:0071356

GO:0120163

GO:0140110

GO:0150079

GO:1903979

GO:1990837

HMNXSV003028744

ILMN_1708249

PH_hs_0014232

TC17001459.hg

TC17002615.hg

X72632_s_at

g13430847_3p_a_at

Participates

as an output of

as an input of

as a member of

NR [nucleoplasm] (Homo sapiens)

as a component of

NR1D1 (REV-ERBA):heme [nucleoplasm] (Homo sapiens)

Inferred To

nr1d1 [nucleoplasm] (Xenopus tropicalis)

nhr-2 [nucleoplasm] (Caenorhabditis elegans)

NR1D1 [nucleoplasm] (Bos taurus)

NR1D1 [nucleoplasm] (Canis familiaris)

NR1D1 [nucleoplasm] (Gallus gallus)

NR1D1 [nucleoplasm] (Mus musculus)

NR1D1 [nucleoplasm] (Rattus norvegicus)

NR1D1 [nucleoplasm] (Sus scrofa)

Eip75B [nucleoplasm] (Drosophila melanogaster)

Homologues of NR1D1 [nucleoplasm] (Caenorhabditis elegans)

nhr-7 [nucleoplasm] (Caenorhabditis elegans)

nhr-85 [nucleoplasm] (Caenorhabditis elegans)

sex-1 [nucleoplasm] (Caenorhabditis elegans)

unc-55 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_068370.1

Guide to Pharmacology - Targets

596

ENSEMBL

ENSG00000126368, ENST00000246672, ENSP00000246672

OpenTargets

ENSG00000126368

ZINC - Substances

NR1D1_HUMAN

ZINC target

P20393

PRO

P20393

PDB

8D8I, 1GA5, 3N00, 1HLZ, 1A6Y

GeneCards

NR1D1

HPA

ENSG00000126368-NR1D1

Pharos - Targets

P20393

ZINC - Predictions - Purchasable

NR1D1_HUMAN

HMDB Protein

HMDBP12681

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75376 NCOR1	2	NCOR1 [nucleoplasm] (R-HSA-442501) NCOR1 [cytosol] (R-HSA-1253310)	0.602	3
UniProt:Q9NZD8 SPG21			0.556	3
UniProt:A0A0S2Z3X1 A0A0S2Z3X1			0.556	3
UniProt:P48775 TDO2	1	TDO2 [cytosol] (R-HSA-71184)	0.556	3
UniProt:P06727 APOA4	5	APOA4 [early endosome] (R-HSA-2429647) APOA4 [cytosol] (R-HSA-2395773) APOA4 [endoplasmic reticulum lumen] (R-HSA-174667) APOA4 [extracellular region] (R-HSA-174701) APOA4(21-94) [extracellular region] (R-HSA-976882)	0.518	3
UniProt:Q7Z6Z7 HUWE1	4	HUWE1 [cytosol] (R-HSA-975983) HUWE1 [ficolin-1-rich granule lumen] (R-HSA-6801467) HUWE1 [extracellular region] (R-HSA-6806466) HUWE1 [secretory granule lumen] (R-HSA-6801481)	0.499	3
UniProt:O54943 Per2	6	Ub-K,p-7S-Per2 [cytosol] (R-MMU-9932499) phospho-Per2 [cytosol] (R-MMU-9932526) p-6S-Per2 [nucleoplasm] (R-MMU-9920666) p-7S-Per2 [cytosol] (R-MMU-9920656) p-S394-Per2 [cytosol] (R-MMU-9920685) Per2 [cytosol] (R-MMU-508621)	0.499	2