Reactome | FGFRL1 modulation of FGFR1 signaling

FGFRL1 modulation of FGFR1 signaling

Stable Identifier

R-HSA-5658623

DOI

10.3180/R-HSA-5658623.2

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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FGFRL1 is a fifth member of the FGFR family of receptors. The extracellular region has 40% sequence similarity with FGFR1-4, but FGFRL1 lacks the internal kinase domain of the other FGF receptors and how it acts in FGFR signaling is unclear. Some models suggest FGFRL1 restricts canonical FGFR signaling by sequestering ligand away from kinase-active receptors, while other models suggest that FGFRL1 may promote canonical signaling by nucleating signaling complexes or enhancing ERK1/2 activation (reviewed in Trueb, 2011; Trueb et al, 2013).

Literature References

PubMed ID	Title	Journal	Year
21080029	Biology of FGFRL1, the fifth fibroblast growth factor receptor Trueb, B	Cell. Mol. Life Sci.	2011
23112089	Role of FGFRL1 and other FGF signaling proteins in early kidney development Amann, R, Trueb, B, Gerber, SD	Cell. Mol. Life Sci.	2013