FGFRL1 binds SPRED1/2

Stable Identifier
R-HSA-5654510
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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FGFRL1 binds SPRED1/2
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FGFRL1 binds to SPRED1 and 2 and Sprouty1 as assessed by co-immunoprecipitation, although the exact stoichiometry of the complex remains to be determined. The interaction requires the C-terminal residues of the short intracellular domain of FGFRL1 (Zhuang et al, 2011). The SPRED proteins are members of the Sprouty family, with established roles as negative regulators of the Ras/Raf/Erk signaling pathway (reviewed in McClatchey and Cichowski, 2012).
Literature References
PubMed ID Title Journal Year
21616146 Interaction of the receptor FGFRL1 with the negative regulator Spred1

Trueb, B, Zhuang, L, Villiger, P

Cell. Signal. 2011
22802525 SPRED proteins provide a NF-ty link to Ras suppression

Cichowski, K, McClatchey, AI

Genes Dev. 2012
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Orthologous Events
FGFRL1 binds SPRED1/2 (Canis familiaris)
FGFRL1 binds SPRED1/2 (Danio rerio)
FGFRL1 binds SPRED1/2 (Drosophila melanogaster)
FGFRL1 binds SPRED1/2 (Gallus gallus)
FGFRL1 binds SPRED1/2 (Mus musculus)
FGFRL1 binds SPRED1/2 (Rattus norvegicus)
FGFRL1 binds SPRED1/2 (Sus scrofa)
FGFRL1 binds SPRED1/2 (Xenopus tropicalis)
Authored
Rothfels, K  (2014-11-20)
Reviewed
Gotoh, N  (2016-03-18)
Grose, RP  (2016-01-06)
Nishimura, T  (2016-01-06)
Created
Rothfels, K  (2014-12-04)
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