FGFRL1 binds SPRED1/2

Stable Identifier
R-HSA-5654510
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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FGFRL1 binds to SPRED1 and 2 and Sprouty1 as assessed by co-immunoprecipitation, although the exact stoichiometry of the complex remains to be determined. The interaction requires the C-terminal residues of the short intracellular domain of FGFRL1 (Zhuang et al, 2011). The SPRED proteins are members of the Sprouty family, with established roles as negative regulators of the Ras/Raf/Erk signaling pathway (reviewed in McClatchey and Cichowski, 2012).

Literature References
PubMed ID Title Journal Year
22802525 SPRED proteins provide a NF-ty link to Ras suppression

McClatchey, AI, Cichowski, K

Genes Dev. 2012
21616146 Interaction of the receptor FGFRL1 with the negative regulator Spred1

Zhuang, L, Villiger, P, Trueb, B

Cell. Signal. 2011
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created