Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1

Stable Identifier
Reaction [binding]
Homo sapiens
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The direct GRB2-binding sites of FRS2 have a major role in activation of the PI3K pathway.

Literature References
PubMed ID Title Journal Year
9632781 Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

Hadari, YR, Kouhara, H, Lax, I, Schlessinger, J

Mol Cell Biol 1998
9182757 A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

Kouhara, H, Hadari, YR, Spivak-Kroizman, T, Schilling, J, Bar-Sagi, D, Lax, I, Schlessinger, J

Cell 1997
14534538 The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3

Agazie, YM, Movilla, N, Ischenko, I, Hayman, MJ

Oncogene 2003
11353842 Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

Ong, SH, Hadari, YR, Gotoh, N, Guy, GR, Schlessinger, J, Lax, I

Proc Natl Acad Sci U S A 2001
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Orthologous Events