The ability of growth factors to protect from apoptosis is primarily due to the activation of the AKT survival pathway. P-I-3-kinase dependent activation of PDK leads to the activation of AKT which in turn affects the activity or expression of pro-apoptotic factors, which contribute to protection from apoptosis. AKT activation also blocks the activity of GSK-3b which could lead to additional antiapoptotic signals.
Pedersen, MV, Risell, M, Meyer, M, Kolkova, K, Berezin, V, Bock, E, Ditlevsen, DK, Kohler, LB
Tynan, JA, Donoghue, DJ, Hart, KC, Kanemitsu, MY, Robertson, SC, Meyer, AN
Schlessinger, J
Schlessinger, J, Eswarakumar, VP, Lax, I
Chapman, BM, Jones, SR, Dai, G, Kamei, T, MCGonigle, KL, Soares, MJ
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