Reactome | Phospholipase C-mediated cascade; FGFR4

Phospholipase C-mediated cascade; FGFR4

Stable Identifier

R-HSA-5654228

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Phospholipase C-gamma (PLC-gamma) is a substrate of the fibroblast growth factor receptor (FGFR) and other receptors with tyrosine kinase activity. It is known that the src homology region 2 (SH2 domain) of PLC-gamma and of other signaling molecules (such as GTPase-activating protein and phosphatidylinositol 3-kinase-associated p85) direct their binding toward autophosphorylated tyrosine residues of the FGFR. Recruitment of PLC-gamma results in its phosphorylation and activation by the receptor. Activated PLC-gamma hydrolyzes phosphatidyl inositol[4,5] P2 to form the second messengers diacylglycerol (DAG) and Ins [1,4,5]P3, which stimulate calcium release and activation of calcium/calmodulin dependent kinases.

Literature References

PubMed ID	Title	Journal	Year
1656221	A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1 Bellot, F, Dionne, CA, Jaye, M, Schlessinger, J, Rotin, D, Honegger, AM, Rubinstein, M, Mohammadi, M, Fischer, R, Li, W	Mol Cell Biol	1991
15863030	Cellular signaling by fibroblast growth factor receptors Schlessinger, J, Eswarakumar, VP, Lax, I	Cytokine Growth Factor Rev	2005
10579907	Phospholipase C-gamma as a signal-transducing element Ji, Q, Carpenter, G	Exp Cell Res	1999