Reactome | Activated FGFR4 phosphorylates PLCG1

Activated FGFR4 phosphorylates PLCG1

Stable Identifier

R-HSA-5654151

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR4 (Homo sapiens)
      - Downstream signaling of activated FGFR4 (Homo sapiens)
        
        Phospholipase C-mediated cascade; FGFR4 (Homo sapiens)
        
        Activated FGFR4 phosphorylates PLCG1 (Homo sapiens)

General

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PLC gamma is phosphorylated by activated FGFR, resulting in PLC gamma activation, stimulation of phosphatidyl inositol hydrolysis and generation of two second messengers, diacylglycerol and inositol (1,4,5) P3. Tyrosine phosphorylation of PLCgamma by FGFR4 is weaker than that seen by other isoforms of FGFR.

Literature References