Activated FGFR4 phosphorylates PLCG1

Stable Identifier
R-HSA-5654151
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Activated FGFR4 phosphorylates PLCG1
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PLC gamma is phosphorylated by activated FGFR, resulting in PLC gamma activation, stimulation of phosphatidyl inositol hydrolysis and generation of two second messengers, diacylglycerol and inositol (1,4,5) P3. Tyrosine phosphorylation of PLCgamma by FGFR4 is weaker than that seen by other isoforms of FGFR.

Literature References
PubMed ID Title Journal Year
10579907 Phospholipase C-gamma as a signal-transducing element

Carpenter, G, Ji, Q

Exp Cell Res 1999
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of activated FGFR4:PLCG1 [plasma membrane]
Physical Entity
activated FGFR4:PLCG1 [plasma membrane]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
Activated FGFR4 phosphorylates PLCG1 (Bos taurus)
Activated FGFR4 phosphorylates PLCG1 (Caenorhabditis elegans)
Activated FGFR4 phosphorylates PLCG1 (Canis familiaris)
Activated FGFR4 phosphorylates PLCG1 (Danio rerio)
Activated FGFR4 phosphorylates PLCG1 (Drosophila melanogaster)
Activated FGFR4 phosphorylates PLCG1 (Gallus gallus)
Activated FGFR4 phosphorylates PLCG1 (Mus musculus)
Activated FGFR4 phosphorylates PLCG1 (Rattus norvegicus)
Activated FGFR4 phosphorylates PLCG1 (Sus scrofa)
Activated FGFR4 phosphorylates PLCG1 (Xenopus tropicalis)
Authored
de Bono, B  (2007-01-10)
Reviewed
Mohammadi, M  (2007-02-07)
Created
Rothfels, K  (2014-12-03)