Reactome | REV1 recruits POLZ to (AP:Cyt)-DNA Template

REV1 recruits POLZ to (AP:Cyt)-DNA Template

Stable Identifier

R-HSA-5652151

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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REV1 recruits POLZ to (AP:Cyt)-DNA Template

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REV1, bound to the replication complex, recruits DNA polymerase zeta (POLZ, REV3L:MAD2L2) to the damaged DNA template. REV3L does not bind REV1 directly. Instead, REV3L binding to MAD2L2 (REV7) during the formation of POLZ complex causes a conformational change in MAD2L2 that allows the C-terminal domain of MAD2L2 to bind the C-terminus of REV1 (Nelson et al. 1996, Hara et al. 2010, Kikuchi et al. 2012, Xie et al. 2012)

Literature References

PubMed ID	Title	Journal	Year
23143872	Structural insights into the assembly of human translesion polymerase complexes Xu, M, Yang, X, Xie, W, Jiang, T	Protein Cell	2012
8751446	Deoxycytidyl transferase activity of yeast REV1 protein Nelson, JR, Hinkle, DC, Lawrence, CW	Nature	1996
22859296	Structural basis of recruitment of DNA polymerase ? by interaction between REV1 and REV7 proteins Hara, K, Kikuchi, S, Hashimoto, H, Sato, M, Shimizu, T	J. Biol. Chem.	2012
20164194	Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1 Murakumo, Y, Takeda, S, Hara, K, Unzai, S, Kogame, T, Sato, M, Hashimoto, H, Akashi, S, Shimizu, T, Kobayashi, S	J. Biol. Chem.	2010