PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate

Stable Identifier
R-HSA-5651723
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
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PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate
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PARP1 or PARP2 homodimers or heterodimers, bound to single strand DNA (ssDNA), POLB and FEN1 at the single strand break (SSB), undergo progressive auto-PARylation causing PARP1/PARP2 to become poly(ADP-ribosyl)ated (Satoh et al. 1994, Prasad et al. 2001).

Literature References
PubMed ID Title Journal Year
8003475 Dual function for poly(ADP-ribose) synthesis in response to DNA strand breakage

Satoh, MS, Poirier, GG, Lindahl, T

Biochemistry 1994
11440997 DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis

Prasad, R, Lavrik, OI, Kim, SJ, Kedar, P, Yang, XP, Vande Berg, BJ, Wilson, SH

J. Biol. Chem. 2001
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
NAD+ ADP-ribosyltransferase activity of PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm]
Physical Entity
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm]
Activity
NAD+ ADP-ribosyltransferase activity (0003950)
Orthologous Events
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Bos taurus)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Canis familiaris)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Danio rerio)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Gallus gallus)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Mus musculus)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Rattus norvegicus)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Sus scrofa)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2014-12-04)
Reviewed
Borowiec, JA  (2014-12-22)
Created
Orlic-Milacic, M  (2014-11-24)