Reactome | PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate

PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate

Stable Identifier

R-HSA-5651723

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate

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PARP1 or PARP2 homodimers or heterodimers, bound to single strand DNA (ssDNA), POLB and FEN1 at the single strand break (SSB), undergo progressive auto-PARylation causing PARP1/PARP2 to become poly(ADP-ribosyl)ated (Satoh et al. 1994, Prasad et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11440997	DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis Prasad, R, Lavrik, OI, Kim, SJ, Kedar, P, Yang, XP, Vande Berg, BJ, Wilson, SH	J. Biol. Chem.	2001
8003475	Dual function for poly(ADP-ribose) synthesis in response to DNA strand breakage Satoh, MS, Poirier, GG, Lindahl, T	Biochemistry	1994