PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate

Stable Identifier
R-HSA-5651723
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PARP1 or PARP2 homodimers or heterodimers, bound to single strand DNA (ssDNA), POLB and FEN1 at the single strand break (SSB), undergo progressive auto-PARylation causing PARP1/PARP2 to become poly(ADP-ribosyl)ated (Satoh et al. 1994, Prasad et al. 2001).

Literature References
PubMed ID Title Journal Year
8003475 Dual function for poly(ADP-ribose) synthesis in response to DNA strand breakage

Satoh, MS, Poirier, GG, Lindahl, T

Biochemistry 1994
11440997 DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis

Prasad, R, Lavrik, OI, Kim, SJ, Kedar, P, Yang, XP, Vande Berg, BJ, Wilson, SH

J. Biol. Chem. 2001
Participants
Participates
Catalyst Activity

NAD+ ADP-ribosyltransferase activity of PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm]

Orthologous Events
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