NEIL1 cleaves FapyA from damaged DNA

Stable Identifier
R-HSA-5649673
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NEIL1 cleaves FapyA from damaged DNA
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
NEIL1 acts as a DNA glycosylase to remove FapyA from damaged DNA, producing an AP (apurinic/apyrimidinic) site (Hazra et al. 2002).
Literature References
PubMed ID Title Journal Year
11904416 Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA

Hazra, TK, Izumi, T, Boldogh, I, Imhoff, B, Kow, YW, Jaruga, P, Dizdaroglu, M, Mitra, S

Proc. Natl. Acad. Sci. U.S.A. 2002
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Catalyst Activity

DNA N-glycosylase activity of NEIL1:FapyA-dsDNA [nucleoplasm]

Physical Entity
NEIL1:FapyA-dsDNA [nucleoplasm] (Homo sapiens)
Activity
DNA N-glycosylase activity (GO:0019104)
Orthologous Events
NEIL1 cleaves FapyA from damaged DNA (Bos taurus)
NEIL1 cleaves FapyA from damaged DNA (Canis familiaris)
NEIL1 cleaves FapyA from damaged DNA (Danio rerio)
NEIL1 cleaves FapyA from damaged DNA (Gallus gallus)
NEIL1 cleaves FapyA from damaged DNA (Mus musculus)
NEIL1 cleaves FapyA from damaged DNA (Rattus norvegicus)
NEIL1 cleaves FapyA from damaged DNA (Sus scrofa)
NEIL1 cleaves FapyA from damaged DNA (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2014-12-04)
Reviewed
Borowiec, JA  (2014-12-22)
Sampath, H  (2019-01-03)
Created
Orlic-Milacic, M  (2014-11-21)
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