Reactome | RAB11A:GTP-containing Golgi vesicles recruit RAB3IP

RAB11A:GTP-containing Golgi vesicles recruit RAB3IP

Stable Identifier

R-HSA-5638014

Type

Reaction [binding]

Species

Homo sapiens

Compartment

Golgi-associated vesicle membrane

ReviewStatus

5/5

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RAB11A:GTP-containing Golgi vesicles recruit RAB3IP

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The RAB8 guanine nucleotide exchange factor RAB3IP/RABIN8 is recruited to vesicles through interaction with membrane-tethered RAB11:GTP (Westlake et al, 2011; Knodler et al, 2010). Recruitment of RAB3IP may also depend on the TRAPPCII complex, a multiprotein complex with roles in vesicular trafficking (Westlake et al, 2011; reviewed in Sacher et al, 2008). RAB3IP is required for RAB8A to localize to the cilium, and depletion of RAB3IP compromises cilia formation (Nachury et al, 2007; Loktev et al, 2008). GTP-bound RAB8A may promote ciliogenesis by promoting the traffic of post-Golgi vesicles to the base of the cilium (Nachury et al, 2007; Westlake et al, 2011; Feng et al, 2012; reviewed in Reiter et al, 2012)

Literature References

PubMed ID	Title	Journal	Year
22653444	The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization Reiter, JF, Blacque, OE, Leroux, MR	EMBO Rep.	2012
20308558	Coordination of Rab8 and Rab11 in primary ciliogenesis Knödler, A, Feng, S, Zhang, J, Zhang, X, Das, A, Peränen, J, Guo, W	Proc. Natl. Acad. Sci. U.S.A.	2010
21273506	Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome Westlake, CJ, Baye, LM, Nachury, MV, Wright, KJ, Ervin, KE, Phu, L, Chalouni, C, Beck, JS, Kirkpatrick, DS, Slusarski, DC, Sheffield, VC, Scheller, RH, Jackson, PK	Proc. Natl. Acad. Sci. U.S.A.	2011
22433857	A Rab8 guanine nucleotide exchange factor-effector interaction network regulates primary ciliogenesis Feng, S, Knödler, A, Ren, J, Zhang, J, Zhang, X, Hong, Y, Huang, S, Peränen, J, Guo, W	J. Biol. Chem.	2012
17574030	A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis Nachury, MV, Loktev, AV, Zhang, Q, Westlake, CJ, Peränen, J, Merdes, A, Slusarski, DC, Scheller, RH, Bazan, JF, Sheffield, VC, Jackson, PK	Cell	2007
18801063	The TRAPP complex: insights into its architecture and function Sacher, M, Kim, YG, Lavie, A, Oh, BH, Segev, N	Traffic	2008
19081074	A BBSome subunit links ciliogenesis, microtubule stability, and acetylation Loktev, AV, Zhang, Q, Beck, JS, Searby, CC, Scheetz, TE, Bazan, JF, Slusarski, DC, Sheffield, VC, Jackson, PK, Nachury, MV	Dev. Cell	2008