RAB11A:GTP-containing Golgi vesicles recruit RAB3IP

Stable Identifier
Reaction [binding]
Homo sapiens
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The RAB8 guanine nucleotide exchange factor RAB3IP/RABIN8 is recruited to vesicles through interaction with membrane-tethered RAB11:GTP (Westlake et al, 2011; Knodler et al, 2010). Recruitment of RAB3IP may also depend on the TRAPPCII complex, a multiprotein complex with roles in vesicular trafficking (Westlake et al, 2011; reviewed in Sacher et al, 2008). RAB3IP is required for RAB8A to localize to the cilium, and depletion of RAB3IP compromises cilia formation (Nachury et al, 2007; Loktev et al, 2008). GTP-bound RAB8A may promote ciliogenesis by promoting the traffic of post-Golgi vesicles to the base of the cilium (Nachury et al, 2007; Westlake et al, 2011; Feng et al, 2012; reviewed in Reiter et al, 2012)

Literature References
PubMed ID Title Journal Year
22653444 The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization

Leroux, MR, Blacque, OE, Reiter, JF

EMBO Rep. 2012
20308558 Coordination of Rab8 and Rab11 in primary ciliogenesis

Das, A, Zhang, J, Zhang, X, Guo, W, Knödler, A, Feng, S, Peränen, J

Proc. Natl. Acad. Sci. U.S.A. 2010
21273506 Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome

Kirkpatrick, DS, Scheller, RH, Ervin, KE, Wright, KJ, Slusarski, DC, Nachury, MV, Westlake, CJ, Baye, LM, Sheffield, VC, Chalouni, C, Jackson, PK, Beck, JS, Phu, L

Proc. Natl. Acad. Sci. U.S.A. 2011
22433857 A Rab8 guanine nucleotide exchange factor-effector interaction network regulates primary ciliogenesis

Zhang, J, Hong, Y, Zhang, X, Huang, S, Guo, W, Knödler, A, Feng, S, Peränen, J, Ren, J

J. Biol. Chem. 2012
17574030 A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis

Westlake, CJ, Loktev, AV, Zhang, Q, Sheffield, VC, Scheller, RH, Slusarski, DC, Nachury, MV, Jackson, PK, Peränen, J, Bazan, JF, Merdes, A

Cell 2007
18801063 The TRAPP complex: insights into its architecture and function

Sacher, M, Segev, N, Kim, YG, Oh, BH, Lavie, A

Traffic 2008
19081074 A BBSome subunit links ciliogenesis, microtubule stability, and acetylation

Scheetz, TE, Searby, CC, Loktev, AV, Zhang, Q, Sheffield, VC, Nachury, MV, Slusarski, DC, Jackson, PK, Beck, JS, Bazan, JF

Dev. Cell 2008
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