Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex

Stable Identifier
R-HSA-5637798
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Recruitment of GRB2:SOS1 complex by SHC1 bound to phosphorylated dimers of EGFRvIII cancer mutant has not been directly tested, but is assumed to happen in the same way it happens with the SHC1 bound to the phosphorylated homodimer of wild-type EGFR (Chardin et al. 1993).
Literature References
PubMed ID Title Journal Year
8493579 Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

Gale, NW, Camonis, JH, Chardin, P, Schlessinger, J, Wigler, MH, Bar-Sagi, D, Van Aelst, L

Science 1993
Participants
Participates
Normal reaction
Functional status

Gain of function of p-5Y-EGFRvIII:p-Y349,Y350-SHC1 [plasma membrane]

Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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