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p-5Y-EGFRvIII:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane]
Stable Identifier
R-HSA-5637704
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by EGFR in Cancer (Homo sapiens)
Signaling by EGFRvIII in Cancer (Homo sapiens)
Constitutive Signaling by EGFRvIII (Homo sapiens)
Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex (Homo sapiens)
p-5Y-EGFRvIII:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII) (Homo sapiens)
p-5Y-EGFRvIII:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Participants
components
GRB2-1:SOS1 [cytosol]
(Homo sapiens)
p-5Y-EGFRvIII:p-Y349,Y350-SHC1 [plasma membrane]
(Homo sapiens)
Participates
as an output of
Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex (Homo sapiens)
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