Phosphorylation of TSC2 by AKT enables association of TSC2 with 14-3-3 proteins YWHAB (14-3-3 protein beta/alpha), YWHAQ (14-3-3 protein theta), YWHAG (14-3-3 protein gamma), YWHAH (14-3-3 protein eta), YWHAE (14-3-3 protein epsilon), YWHAZ (14-3-3 protein zeta/delta) or SFN (14-3-3 protein sigma) (Liu et al. 2002). Binding to 14-3-3 proteins sequesters TSC2 to the cytosol and prevents its association with TSC1 (Cai et al. 2006).
Cai, SL, Tee, AR, Short, JD, Bergeron, JM, Kim, J, Shen, J, Guo, R, Johnson, CL, Kiguchi, K, Walker, CL
Liu, MY, Cai, S, Espejo, A, Bedford, MT, Walker, CL
© 2021 Reactome