Reactome | p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4

p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4

Stable Identifier

R-HSA-5632732

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphorylation of TSC2 by AKT enables association of TSC2 with 14-3-3 proteins YWHAB (14-3-3 protein beta/alpha), YWHAQ (14-3-3 protein theta), YWHAG (14-3-3 protein gamma), YWHAH (14-3-3 protein eta), YWHAE (14-3-3 protein epsilon), YWHAZ (14-3-3 protein zeta/delta) or SFN (14-3-3 protein sigma) (Liu et al. 2002). Binding to 14-3-3 proteins sequesters TSC2 to the cytosol and prevents its association with TSC1 (Cai et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
12438239	14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s) Liu, MY, Cai, S, Espejo, A, Bedford, MT, Walker, CL	Cancer Res.	2002
16636147	Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning Cai, SL, Tee, AR, Short, JD, Bergeron, JM, Kim, J, Shen, J, Guo, R, Johnson, CL, Kiguchi, K, Walker, CL	J. Cell Biol.	2006