Reactome | TNPO1 binds KIF17 dimer

TNPO1 binds KIF17 dimer

Stable Identifier

R-HSA-5624951

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

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KIF17 is an alternate kinesin-2 motor that is required in some cell types for anterograde IFT and for the ciliary localization of CNG (Ou et al, 2005; Jenkins et al, 2006; Insinna et al, 2008; Insinna et al, 2009; Li et al, 2010; reviewed in Scholey, 2008; Verhey et al, 2011). KIF17 contains a C-terminal ciliary localization signal that mediates its interaction with nuclear import factor TNPO1 (importin beta-2). This interaction is required for the ciliary targeting of KIF17 and is regulated by RAN GTP levels such that the interaction is promoted in the cytosol where RAN:GTP levels are low, and is destabilized in the cilium where RAN:GTP levels are high (Dishinger et al, 2010). The roles of TNPO1 and the RAN:GTP gradient in promoting ciliary localization of KIF17 are analogous to their roles in nuclear import and provide evidence for the first time of conserved mechanisms governing nuclear and ciliary localization (Dishinger et al, 2010; Devos et al, 2004; Gruss, 2010).

Literature References

PubMed ID	Title	Journal	Year
21936775	Kinesin motors and primary cilia Verhey, KJ, Dishinger, J, Kee, HL	Biochem. Soc. Trans.	2011
15523559	Components of coated vesicles and nuclear pore complexes share a common molecular architecture Devos, D, Dokudovskaya, S, Alber, F, Williams, R, Chait, BT, Sali, A, Rout, MP	PLoS Biol.	2004
19384852	Different roles for KIF17 and kinesin II in photoreceptor development and maintenance Insinna, C, Humby, M, Sedmak, T, Wolfrum, U, Besharse, JC	Dev. Dyn.	2009
16049494	Functional coordination of intraflagellar transport motors Ou, G, Blacque, OE, Snow, JJ, Leroux, MR, Scholey, JM	Nature	2005
20526327	Nuclear transport receptor goes moonlighting Gruss, OJ	Nat. Cell Biol.	2010
16782012	Ciliary targeting of olfactory CNG channels requires the CNGB1b subunit and the kinesin-2 motor protein, KIF17 Jenkins, PM, Hurd, TW, Zhang, L, McEwen, DP, Brown, RL, Margolis, B, Verhey, KJ, Martens, JR	Curr. Biol.	2006
20530210	The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis Li, Y, Wei, Q, Zhang, Y, Ling, K, Hu, J	J. Cell Biol.	2010
18180368	Intraflagellar transport motors in cilia: moving along the cell's antenna Scholey, JM	J. Cell Biol.	2008
18304522	The homodimeric kinesin, Kif17, is essential for vertebrate photoreceptor sensory outer segment development Insinna, C, Pathak, N, Perkins, B, Drummond, I, Besharse, JC	Dev. Biol.	2008
20526328	Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP Dishinger, JF, Kee, HL, Jenkins, PM, Fan, S, Hurd, TW, Hammond, JW, Truong, YN, Margolis, B, Martens, JR, Verhey, KJ	Nat. Cell Biol.	2010