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SLC22A3 [plasma membrane]
Stable Identifier
R-HSA-549257
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
OCT3, Solute carrier family 22 member 3, S22A3_HUMAN
Locations in the PathwayBrowser
Expand all
Drug ADME (Homo sapiens)
Abacavir ADME (Homo sapiens)
Abacavir transmembrane transport (Homo sapiens)
abacavir [extracellular] => abacavir [cytosol] (Homo sapiens)
SLC22A1,2,3 [plasma membrane] (Homo sapiens)
SLC22A3 [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Organic cation/anion/zwitterion transport (Homo sapiens)
Organic cation transport (Homo sapiens)
OCT3 mediates renal clearance of organic cations (Homo sapiens)
SLC22A3 [plasma membrane] (Homo sapiens)
OCT3 mediates renal uptake of organic cations (Homo sapiens)
SLC22A3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75751 SLC22A3
Gene Names
SLC22A3, EMTH, OCT3
Chain
chain:1-556
Reference Genes
BioGPS Gene:6581 SLC22A3
COSMIC (genes):SLC22A3 SLC22A3
CTD Gene:6581 SLC22A3
dbSNP Gene:6581 SLC22A3
ENSEMBL:ENSG00000146477 SLC22A3
ENSEMBL:ENSG00000146477.6 SLC22A3
HGNC:10967 SLC22A3
KEGG Gene (Homo sapiens):6581 SLC22A3
Monarch:6581 SLC22A3
NCBI Gene:6581 SLC22A3
OMIM:604842 SLC22A3
UCSC:O75751 SLC22A3
Reference Transcript
RefSeq:NM_021977.3 SLC22A3
Other Identifiers
11736281_a_at
17014442
205421_PM_at
205421_at
2934522
2934523
2934524
2934535
2934537
2934538
2934539
2934559
2934560
2934561
2934562
2934572
2934575
2934576
2934577
2934578
2982895
6581
8123246
A_14_P111760
A_23_P19733
GE79414
GO:0001692
GO:0003013
GO:0005215
GO:0005326
GO:0005515
GO:0005634
GO:0005635
GO:0005640
GO:0005739
GO:0005886
GO:0006811
GO:0006836
GO:0006837
GO:0008504
GO:0008514
GO:0012505
GO:0015101
GO:0015606
GO:0015651
GO:0015695
GO:0015697
GO:0015711
GO:0015718
GO:0015844
GO:0015848
GO:0015850
GO:0015872
GO:0015874
GO:0016020
GO:0016323
GO:0016324
GO:0019534
GO:0022857
GO:0031965
GO:0031966
GO:0032098
GO:0042908
GO:0043025
GO:0043226
GO:0048241
GO:0051608
GO:0051610
GO:0051615
GO:0051620
GO:0051625
GO:0051649
GO:0055085
GO:0072530
GO:0090494
GO:0098793
GO:0150104
GO:1901998
GO:1903711
HMNXSV003027475
HMNXSV003045734
PH_hs_0032275
TC06001156.hg
g11415037_3p_at
Participates
as a member of
SLC22A1,2,3 [plasma membrane] (Homo sapiens)
Inferred To
Orct [plasma membrane]
(Drosophila melanogaster)
Dmel\CG16727 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG14855 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG4630 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG7342 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG10486 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG6356 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG5592 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG8925 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG6006 [plasma membrane]
(Drosophila melanogaster)
SLC22A3 [plasma membrane]
(Bos taurus)
SLC22A3 [plasma membrane]
(Caenorhabditis elegans)
SLC22A3 [plasma membrane]
(Canis familiaris)
SLC22A3 [plasma membrane]
(Gallus gallus)
SLC22A3 [plasma membrane]
(Sus scrofa)
Slc22a3 [plasma membrane]
(Mus musculus)
Slc22a3 [plasma membrane]
(Rattus norvegicus)
CG6596 [plasma membrane]
(Drosophila melanogaster)
CT19169 [plasma membrane]
(Drosophila melanogaster)
CarT [plasma membrane]
(Drosophila melanogaster)
CG31530-RA [plasma membrane]
(Drosophila melanogaster)
CG8654-RA [plasma membrane]
(Drosophila melanogaster)
Dmel\CG17752 [plasma membrane]
(Drosophila melanogaster)
Homologues of SLC22A3 [plasma membrane]
(Caenorhabditis elegans)
Homologues of SLC22A3 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG7333 [plasma membrane]
(Drosophila melanogaster)
Orct2 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG4465 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG14857 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG4462 [plasma membrane]
(Drosophila melanogaster)
oct-1 [plasma membrane]
(Caenorhabditis elegans)
Dmel\CG7084 [plasma membrane]
(Drosophila melanogaster)
Balat [plasma membrane]
(Drosophila melanogaster)
Dmel\CG14856 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG6231 [plasma membrane]
(Drosophila melanogaster)
SLC22A [plasma membrane]
(Drosophila melanogaster)
Dmel\CG17751 [plasma membrane]
(Drosophila melanogaster)
slc22a3 [plasma membrane]
(Danio rerio)
Dmel\CG7458 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG4459 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_068812.1
ZINC - World Drugs
S22A3_HUMAN
Guide to Pharmacology - Targets
1021
OpenTargets
ENSG00000146477
ZINC - FDA approved
S22A3_HUMAN
ZINC - Substances
S22A3_HUMAN
ZINC - Biogenic
S22A3_HUMAN
ZINC target
O75751
PRO
O75751
PDB
7ZH6
,
7ZHA
,
7ZH0
ZINC - Investigational
S22A3_HUMAN
ZINC - Metabolites
S22A3_HUMAN
HPA
ENSG00000146477-SLC22A3
GeneCards
O75751
Ensembl
ENSP00000275300
,
ENSG00000146477
,
ENST00000275300
Pharos - Targets
O75751
ZINC - Predictions - Purchasable
S22A3_HUMAN
HMDB Protein
HMDBP04309
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