Reactome | MED11 [nucleoplasm]

MED11 [nucleoplasm]

Stable Identifier

R-HSA-556808

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Mediator of RNA polymerase II transcription subunit 11, MED11_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
      - RSV-host interactions (Homo sapiens)
        
        NS1 (1C) binds to Mediator complex (Homo sapiens)
        
        Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
        
        MED11 [nucleoplasm] (Homo sapiens)
        
        Mediator:NS1 [nucleoplasm] (Homo sapiens)
        
        Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
        
        MED11 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9P086 MED11

Gene Names

MED11, HSPC296

Chain

initiator methionine:, chain:2-117

Reference Genes

BioGPS Gene:400569 MED11

COSMIC (genes):MED11 MED11

CTD Gene:400569 MED11

dbSNP Gene:400569 MED11

ENSEMBL:ENSG00000161920 MED11

HGNC:32687 MED11

KEGG:hsa:400569 MED11

Monarch:400569 MED11

NCBI Gene:400569 MED11

OMIM:612383 MED11

UCSC:Q9P086 MED11

Reference Transcript

Other Identifiers

11717961_at

16829852

226958_PM_s_at

226958_s_at

3707128

3707129

3707130

3707133

3707134

3707136

3707137

3707138

3707139

3707140

400569

55057_at

8003922

ADDON002626.hg

A_23_P425587

GE484220

GO:0000151

GO:0003712

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0006355

GO:0006357

GO:0016567

GO:0016592

GO:0016740

GO:0032968

GO:0043226

GO:0051123

GO:0060090

GO:0060261

GO:0061630

GO:0065003

GO:0070847

GO:0140096

GO:0140110

HMNXSV003034183

Hs.82407.1.S1_3p_a_at

ILMN_1762639

TC17000048.hg

Participates

as a component of

Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001001683.1, NP_001291929.1

OpenTargets

ENSG00000161920

ENSEMBL

ENSP00000293777, ENST00000293777

HPA

ENSG00000161920-MED11

PRO

Q9P086

Pharos - Targets

Q9P086

PDB

7LBM, 7ENC, 7ENA, 7NVR, 8GXQ, 7ENJ, 8GXS, 7EMF

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BTT4 MED10	1	MED10 [nucleoplasm] (R-HSA-212410)	0.901	9
UniProt:P49336 CDK8	1	CDK8 [nucleoplasm] (R-HSA-212440)	0.745	7
UniProt:O43513 MED7	1	MED7 [nucleoplasm] (R-HSA-212430)	0.725	5
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.671	6
UniProt:Q9H944 MED20	1	MED20 [nucleoplasm] (R-HSA-212428)	0.643	4
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.643	4
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.643	4
UniProt:Q93074 MED12	1	MED12 [nucleoplasm] (R-HSA-212343)	0.643	3
UniProt:Q9NVC6 MED17	1	MED17 [nucleoplasm] (R-HSA-212401)	0.643	4
UniProt:Q96G25 MED8	1	MED8 [nucleoplasm] (R-HSA-556784)	0.564	2
UniProt:P23434 GCSH	3	octanoyl-K107-GCSH [mitochondrial matrix] (R-HSA-6793586) Lipo-K107-GCSH [mitochondrial matrix] (R-HSA-6793611) GCSH [mitochondrial matrix] (R-HSA-5693951)	0.556	3
UniProt:Q6PIF2 SYCE2	1	SYCE2 [nucleoplasm] (R-HSA-912451)	0.556	3
UniProt:A1L4H1 SSC5D	1	SSC5D [extracellular region] (R-HSA-8878615)	0.556	3
UniProt:Q96ES7 SGF29	1	SGF29 [nucleoplasm] (R-HSA-3662279)	0.556	3
UniProt:Q9Y3C7 MED31	1	MED31 [nucleoplasm] (R-HSA-212429)	0.527	2
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.527	3
UniProt:O75448 MED24	1	MED24 [nucleoplasm] (R-HSA-212331)	0.527	3
UniProt:Q9ULK4 MED23	1	MED23 [nucleoplasm] (R-HSA-556823)	0.527	2
UniProt:Q96HR3 MED30	1	MED30 [nucleoplasm] (R-HSA-212398)	0.527	2