OCT2 mediates tubular uptake of organic cations in the kidney

Stable Identifier
Reaction [transition]
Homo sapiens
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The human gene SLC22A2 encodes the organic cation transporter OCT2. It is expressed in a variety of tissues, especially the kidney and placenta. OCT2 can mediate the reversible transport of a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN) and 4-(4-(dimethylamino)styryl)-N-methylpyridinium (Gorboulev et al. 1997). Pharmaceuticals that up-regulate OCT2 in the kidney can increase the renal excretion of cationic drugs. The transport activity of OCT2 was decreased upon co-expression of regulatory solute carrier protein family 1 member 1 (RSC1A1, aka RS1). RSC1A1 exhibits glucose-dependent, short-term inhibition of OCT2 by inhibiting the release of vesicles from the trans-Golgi network (Veyhl et al. 2006).
Literature References
PubMed ID Title Journal Year
9260930 Cloning and characterization of two human polyspecific organic cation transporters

Koepsell, H, Ulzheimer, JC, Quester, S, Busch, AE, Akhoundova, A, Lang, F, Baumann, C, Karbach, U, Gorboulev, V, Ulzheimer-Teuber, I

DNA Cell Biol 1997
16788146 RS1 (RSC1A1) regulates the exocytotic pathway of Na+-D-glucose cotransporter SGLT1

Koepsell, H, Vernaleken, A, Veyhl, M, Keller, T, Gorboulev, V

Am. J. Physiol. Renal Physiol. 2006
Event Information
Catalyst Activity

organic cation transmembrane transporter activity of SLC22A1,SLC22A2 [plasma membrane]

This event is regulated
Negatively by
Orthologous Events
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