Reactome | OCT2 mediates tubular secretion of organic cations in the kidney

OCT2 mediates tubular secretion of organic cations in the kidney

Stable Identifier

R-HSA-561054

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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OCT2 mediates tubular secretion of organic cations in the kidney

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The human gene SLC22A2 encodes the organic cation transporter OCT2. It is expressed in a variety of tissues, especially the kidney and placenta. OCT2 can mediate the reversible transport of a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN) and 4-(4-(dimethylamino)styryl)-N-methylpyridinium (Gorboulev et al. 1997). Pharmaceuticals that up-regulate OCT2 in the kidney can increase the renal excretion of cationic drugs. The transport activity of OCT2 was decreased upon co-expression of regulatory solute carrier protein family 1 member 1 (RSC1A1, aka RS1). RSC1A1 exhibits glucose-dependent, short-term inhibition of OCT2 by inhibiting the release of vesicles from the trans-Golgi network (Veyhl et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
9260930	Cloning and characterization of two human polyspecific organic cation transporters Gorboulev, V, Ulzheimer, JC, Akhoundova, A, Ulzheimer-Teuber, I, Karbach, U, Quester, S, Baumann, C, Lang, F, Busch, AE, Koepsell, H	DNA Cell Biol	1997
16788146	RS1 (RSC1A1) regulates the exocytotic pathway of Na+-D-glucose cotransporter SGLT1 Veyhl, M, Keller, T, Gorboulev, V, Vernaleken, A, Koepsell, H	Am. J. Physiol. Renal Physiol.	2006