CYP1A2 hydroxylates AFB1 to AFM1

Stable Identifier
R-HSA-5423678
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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CYP1A2 hydroxylates AFB1 to AFM1
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Aflatoxin B1 (AFB1) undergoes extensive oxidation, which is catalysed by cytochrome P450s. In addition to formation of the 8,9-oxide, oxidation by CYP1A2 yields a stable metabolite, aflatoxin M1 (AFM1), that is excreted in milk and urine (Ueng et al. 1995). AFM1 is less carcinogenic or mutagenic than AFB1, but is equally toxic.
Literature References
PubMed ID Title Journal Year
7766804 Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes

Guengerich, FP, Yamazaki, H, Ueng, YF, Shimada, T

Chem. Res. Toxicol. 1995
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Catalyst Activity

monooxygenase activity of CYP1A2 [endoplasmic reticulum membrane]

Physical Entity
CYP1A2 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
monooxygenase activity (GO:0004497)
Orthologous Events
CYP1A2 hydroxylates AFB1 to AFM1 (Bos taurus)
CYP1A2 hydroxylates AFB1 to AFM1 (Danio rerio)
CYP1A2 hydroxylates AFB1 to AFM1 (Gallus gallus)
CYP1A2 hydroxylates AFB1 to AFM1 (Mus musculus)
CYP1A2 hydroxylates AFB1 to AFM1 (Rattus norvegicus)
CYP1A2 hydroxylates AFB1 to AFM1 (Sus scrofa)
Authored
Jassal, B  (2014-05-09)
Reviewed
D'Eustachio, P  (2014-05-22)
Created
Jassal, B  (2014-05-09)
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