CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [endoplasmic reticulum lumen]

Stable Identifier
R-HSA-5362447
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
Sonic hedgehog protein N product, SHH, SHH_HUMAN
Icon
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [endoplasmic reticulum lumen] icon
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [endoplasmic reticulum lumen] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:Q15465 SHH
Gene Names
SHH
Chain
signal peptide:1-23, chain:24-462, chain:24-197
Reference Genes
BioGPS Gene:6469 SHH
COSMIC (genes):SHH SHH
CTD Gene:6469 SHH
dbSNP Gene:6469 SHH
ENSEMBL:ENSG00000164690 SHH
HGNC:10848 SHH
KEGG:hsa:6469 SHH
Monarch:6469 SHH
NCBI Gene:6469 SHH
OMIM:600725 SHH
UCSC:Q15465 SHH
Reference Transcript
Other Identifiers
11738265_at
17064810
207586_PM_at
207586_at
236263_PM_at
236263_at
3081218
3081219
3081220
3081221
3081222
3081223
3081224
3081225
3081226
3081227
3081229
3081230
3081231
31724_at
59360_at
6469
70121_at
8144078
A_23_P111657
GE619667
GO:0000122
GO:0000139
GO:0001525
GO:0001569
GO:0001570
GO:0001656
GO:0001658
GO:0001708
GO:0001755
GO:0001822
GO:0001942
GO:0001944
GO:0001947
GO:0002052
GO:0002053
GO:0002076
GO:0002320
GO:0002376
GO:0003140
GO:0003824
GO:0004175
GO:0005113
GO:0005509
GO:0005515
GO:0005539
GO:0005576
GO:0005615
GO:0005783
GO:0005788
GO:0005789
GO:0005794
GO:0005829
GO:0005886
GO:0006355
GO:0006508
GO:0006606
GO:0006629
GO:0006886
GO:0006897
GO:0006913
GO:0007010
GO:0007163
GO:0007224
GO:0007267
GO:0007275
GO:0007368
GO:0007389
GO:0007398
GO:0007405
GO:0007411
GO:0007417
GO:0007418
GO:0007442
GO:0007507
GO:0007519
GO:0007596
GO:0008209
GO:0008233
GO:0008270
GO:0008283
GO:0008284
GO:0009880
GO:0009888
GO:0009949
GO:0009952
GO:0009953
GO:0009986
GO:0010463
GO:0010467
GO:0010468
GO:0010628
GO:0010629
GO:0012501
GO:0014003
GO:0014706
GO:0014856
GO:0014858
GO:0014902
GO:0016015
GO:0016020
GO:0016192
GO:0016477
GO:0016539
GO:0016540
GO:0016740
GO:0016787
GO:0021513
GO:0021522
GO:0021794
GO:0021871
GO:0021904
GO:0021924
GO:0021930
GO:0021940
GO:0021978
GO:0022414
GO:0023052
GO:0030154
GO:0030162
GO:0030177
GO:0030178
GO:0030182
GO:0030312
GO:0030323
GO:0030324
GO:0030326
GO:0030336
GO:0030539
GO:0030850
GO:0030878
GO:0030900
GO:0030901
GO:0030902
GO:0031012
GO:0031016
GO:0031069
GO:0032435
GO:0033077
GO:0033085
GO:0033089
GO:0033092
GO:0034244
GO:0034504
GO:0035115
GO:0035116
GO:0035295
GO:0036484
GO:0042098
GO:0042127
GO:0042130
GO:0042177
GO:0042307
GO:0042475
GO:0042476
GO:0042481
GO:0042733
GO:0043010
GO:0043066
GO:0043226
GO:0043237
GO:0043369
GO:0043588
GO:0045059
GO:0045060
GO:0045109
GO:0045121
GO:0045165
GO:0045445
GO:0045596
GO:0045665
GO:0045880
GO:0045893
GO:0045944
GO:0046632
GO:0046638
GO:0046639
GO:0046872
GO:0048018
GO:0048468
GO:0048513
GO:0048538
GO:0048546
GO:0048557
GO:0048568
GO:0048589
GO:0048598
GO:0048617
GO:0048643
GO:0048645
GO:0048646
GO:0048663
GO:0048706
GO:0048708
GO:0048709
GO:0048711
GO:0048714
GO:0048745
GO:0048754
GO:0048839
GO:0048856
GO:0048859
GO:0048864
GO:0048870
GO:0050673
GO:0050679
GO:0050793
GO:0051146
GO:0051155
GO:0051604
GO:0051781
GO:0060020
GO:0060021
GO:0060070
GO:0060173
GO:0060174
GO:0060251
GO:0060425
GO:0060428
GO:0060438
GO:0060439
GO:0060441
GO:0060442
GO:0060445
GO:0060447
GO:0060458
GO:0060459
GO:0060463
GO:0060484
GO:0060516
GO:0060523
GO:0060662
GO:0060664
GO:0060684
GO:0060685
GO:0060738
GO:0060767
GO:0060768
GO:0060769
GO:0060782
GO:0060783
GO:0060840
GO:0060916
GO:0061053
GO:0061189
GO:0062023
GO:0071285
GO:0071542
GO:0072089
GO:0072091
GO:0072136
GO:0072205
GO:0090090
GO:0090162
GO:0090370
GO:0097152
GO:0097190
GO:0097264
GO:0098528
GO:0098772
GO:0140096
GO:0140853
GO:1900180
GO:1904339
GO:1905327
GO:2000062
GO:2000063
GO:2000357
GO:2000358
GO:2000729
GO:2001054
HMNXSV003038694
Hs.164537.0.A1_3p_at
ILMN_1652693
PH_hs_0006769
PH_hs_0009949
TC07002064.hg
g4506938_3p_at
p28827
p33937
Participates
as a member of
Other forms of this molecule
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [extracellular region]
ub-N4glycoAsn-SHH(198-462) [endoplasmic reticulum lumen]
ub-N4glycoAsn-SHH(198-462) [cytosol]
2xHC-SHH(24-462) [endoplasmic reticulum lumen]
N4glycoAsn-SHH(198-462) [endoplasmic reticulum lumen]
CHOL-SHH(24-197) [endoplasmic reticulum lumen]
N4glycoAsn-2xHC-SHH(24-462) [endoplasmic reticulum lumen]
SHH(24-462) C198S [endoplasmic reticulum lumen]
SHH(24-462) W117G [endoplasmic reticulum lumen]
SHH(24-462) H374R [endoplasmic reticulum lumen]
SHH(24-462) L382P [endoplasmic reticulum lumen]
SHH(24-462) A383T [endoplasmic reticulum lumen]
SHH(24-462) A376D [endoplasmic reticulum lumen]
SHH(24-462) P377S [endoplasmic reticulum lumen]
SHH(24-462) R381P [endoplasmic reticulum lumen]
SHH(24-462) A373T [endoplasmic reticulum lumen]
SHH(24-462) C198F [endoplasmic reticulum lumen]
SHH(24-462) G196E [endoplasmic reticulum lumen]
SHH(24-462) G196V [endoplasmic reticulum lumen]
SHH(34-?) [extracellular region]
SHH(24-462) [endoplasmic reticulum lumen]
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [plasma membrane]
ub SHH(24-462) W117G [cytosol]
ub SHH(24-462) A373T [cytosol]
ub SHH(24-462) H374R [cytosol]
ub SHH(24-462) A383T [cytosol]
ub SHH(24-462) P377S [cytosol]
ub SHH(24-462) A376D [cytosol]
ub SHH(24-462) R381P [cytosol]
ub SHH(24-462) L382P [cytosol]
ub SHH(24-462) G196V [cytosol]
ub SHH(24-462) C198F [cytosol]
ub SHH(24-462) G196E [cytosol]
ub SHH(24-462) W117R [cytosol]
ub SHH(24-462) C198S [cytosol]
ub-SHH(24-462) W117R [endoplasmic reticulum lumen]
ub-SHH(24-462) W117G [endoplasmic reticulum lumen]
ub-SHH(24-462) A373T [endoplasmic reticulum lumen]
ub-SHH(24-462) L382P [endoplasmic reticulum lumen]
ub-SHH(24-462) P377S [endoplasmic reticulum lumen]
ub-SHH(24-462) A383T [endoplasmic reticulum lumen]
ub-SHH(24-462) H374R [endoplasmic reticulum lumen]
ub-SHH(24-462) R381P [endoplasmic reticulum lumen]
ub-SHH(24-462) A376D [endoplasmic reticulum lumen]
ub-SHH(24-462) C198F [endoplasmic reticulum lumen]
ub-SHH(24-462) G196E [endoplasmic reticulum lumen]
ub-SHH(24-462) G196V [endoplasmic reticulum lumen]
ub-SHH(24-462) C198S [endoplasmic reticulum lumen]
SHH(24-462) W117R [endoplasmic reticulum lumen]
Inferred To
SHH [endoplasmic reticulum lumen] (Canis familiaris)
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [endoplasmic reticulum lumen] (Bos taurus)
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [endoplasmic reticulum lumen] (Danio rerio)
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [endoplasmic reticulum lumen] (Drosophila melanogaster)
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [endoplasmic reticulum lumen] (Gallus gallus)
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [endoplasmic reticulum lumen] (Mus musculus)
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [endoplasmic reticulum lumen] (Rattus norvegicus)
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [endoplasmic reticulum lumen] (Sus scrofa)
CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [endoplasmic reticulum lumen] (Xenopus tropicalis)
Modified Residues
Name
glycine cholesterol ester at 197
Coordinate
197
PsiMod Name
glycine cholesterol ester [MOD:00314]
PsiMod Definition
A protein modification that effectively converts a glycine residue to glycine cholesterol ester.
Name
N-palmitoyl-L-cysteine at 24
Coordinate
24
PsiMod Name
N-palmitoyl-L-cysteine [MOD:00069]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-L-cysteine.
Cross References
ZINC - World Drugs
OpenTargets
ENSEMBL
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
GlyGen
PDB
ZINC - Metabolites
HPA
Pharos - Targets
Orphanet
SHH
ZINC - Predictions - Purchasable
Interactors (2)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q13635-1 PTCH1      0.781 11
 UniProt:Q96QV1 HHIP  1 0.691 10
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