Reactome | HHIP [ciliary membrane]

HHIP [ciliary membrane]

Stable Identifier

R-HSA-445449

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ciliary membrane

Synonyms

Hedgehog-interacting protein, HHIP_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q96QV1 HHIP

Gene Names

HHIP, HIP, UNQ5825/PRO19644

Chain

signal peptide:1-17, chain:18-700

Reference Genes

BioGPS Gene:64399 HHIP

COSMIC (genes):HHIP HHIP

CTD Gene:64399 HHIP

dbSNP Gene:64399 HHIP

ENSEMBL:ENSG00000164161 HHIP

ENSEMBL:ENSG00000164161.10 HHIP

HGNC:14866 HHIP

KEGG Gene (Homo sapiens):64399 HHIP

Monarch:64399 HHIP

NCBI Gene:64399 HHIP

OMIM:606178 HHIP

UCSC:Q96QV1 HHIP

Reference Transcript

RefSeq:NM_022475.2 HHIP

Other Identifiers

11736086_a_at

11754706_a_at

11756007_a_at

1556037_PM_s_at

1556037_s_at

16971102

223775_PM_at

223775_at

230135_PM_at

230135_at

237466_PM_s_at

237466_s_at

2745914

2745915

2745916

2745917

2745919

2745922

2745923

2745924

2745925

2745936

2745938

2745940

2745942

2745943

2745944

2745946

2745950

2745951

2745952

2745953

2745954

2745959

2745961

2745963

2745965

2745967

2745969

2745970

54570_at

62182_at

64399

8097628

ADDON000808.hg

ADDON001411.hg

A_14_P103704

A_14_P114103

A_14_P120008

A_14_P201676

A_21_P0014446

A_23_P167129

A_24_P401842

A_32_P11262

GE63126

GE727316

GO:0005515

GO:0005576

GO:0005737

GO:0005886

GO:0005929

GO:0007165

GO:0007405

GO:0008270

GO:0009887

GO:0009953

GO:0009968

GO:0009986

GO:0012501

GO:0016020

GO:0023052

GO:0030154

GO:0040036

GO:0043066

GO:0043226

GO:0045879

GO:0046872

GO:0048705

GO:0048856

GO:0060170

GO:0060441

GO:0097108

HMNXSV003010689

HMNXSV003024105

HMNXSV003024910

Hs.256982.0.A1_3p_at

Hs.256982.0.A1_3p_s_at

Hs.49265.0.A1_3p_at

Hs2.378938.1.S1_3p_s_at

ILMN_1675453

ILMN_1905863

ILMN_2204215

PH_hs_0003434

PH_hs_0024950

TC04000706.hg

g11528009_3p_at

p25322

Participates

as a component of

Hh-Npp:HHIP [ciliary membrane] (Homo sapiens)

as an input of

HHIP binds Hedgehog (Homo sapiens)

Inferred To

HHIP [ciliary membrane] (Bos taurus)

HHIP [ciliary membrane] (Canis familiaris)

HHIP [ciliary membrane] (Danio rerio)

HHIP [ciliary membrane] (Gallus gallus)

HHIP [ciliary membrane] (Mus musculus)

HHIP [ciliary membrane] (Sus scrofa)

Hhip [ciliary membrane] (Rattus norvegicus)

hhip [ciliary membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_071920.1

OpenTargets

ENSG00000164161

HPA

ENSG00000164161-HHIP

GeneCards

Q96QV1

Ensembl

ENSG00000164161, ENST00000296575, ENSP00000296575, ENSP00000408587, ENST00000434550

PRO

Q96QV1

Pharos - Targets

Q96QV1

PDB

2WG4, 2WFX, 2WFT, 7PGL, 2WG3, 7PGN, 3HO4, 3HO3, 3HO5, 7PGM, 7PGK

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15465 SHH	20	CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [extracellular region] (R-HSA-445140) CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [plasma membrane] (R-HSA-5362407) CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [endoplasmic reticulum lumen] (R-HSA-5362447) ub-N4glycoAsn-SHH(198-462) [endoplasmic reticulum lumen] (R-HSA-5362416) ub-N4glycoAsn-SHH(198-462) [cytosol] (R-HSA-5362394) 2xHC-SHH(24-462) [endoplasmic reticulum lumen] (R-HSA-5358280) N4glycoAsn-SHH(198-462) [endoplasmic reticulum lumen] (R-HSA-5358289) CHOL-SHH(24-197) [endoplasmic reticulum lumen] (R-HSA-5358296) N4glycoAsn-2xHC-SHH(24-462) [endoplasmic reticulum lumen] (R-HSA-5362384) SHH(24-462) C198S [endoplasmic reticulum lumen] (R-HSA-5358439) SHH(24-462) W117G [endoplasmic reticulum lumen] (R-HSA-5358404) SHH(24-462) H374R [endoplasmic reticulum lumen] (R-HSA-5358430) SHH(24-462) L382P [endoplasmic reticulum lumen] (R-HSA-5358428) SHH(24-462) A383T [endoplasmic reticulum lumen] (R-HSA-5358444) SHH(24-462) A376D [endoplasmic reticulum lumen] (R-HSA-5358445) SHH(24-462) P377S [endoplasmic reticulum lumen] (R-HSA-5358427) SHH(24-462) R381P [endoplasmic reticulum lumen] (R-HSA-5358425) SHH(24-462) A373T [endoplasmic reticulum lumen] (R-HSA-5358448) SHH(24-462) C198F [endoplasmic reticulum lumen] (R-HSA-5358441) SHH(24-462) G196E [endoplasmic reticulum lumen] (R-HSA-5358437)	0.691	10

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