Reactome | HHIP [ciliary membrane]

HHIP [ciliary membrane]

Stable Identifier

R-HSA-445449

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ciliary membrane

Synonyms

Hedgehog-interacting protein, HHIP_HUMAN

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External Reference Information

External Reference

UniProt:Q96QV1 HHIP

Gene Names

HHIP, HIP, UNQ5825/PRO19644

Chain

signal peptide:1-17, chain:18-700

Reference Genes

BioGPS Gene:64399 HHIP

COSMIC (genes):HHIP HHIP

CTD Gene:64399 HHIP

dbSNP Gene:64399 HHIP

ENSEMBL:ENSG00000164161 HHIP

HGNC:14866 HHIP

KEGG:hsa:64399 HHIP

Monarch:64399 HHIP

NCBI Gene:64399 HHIP

OMIM:606178 HHIP

UCSC:Q96QV1 HHIP

Reference Transcript

RefSeq:NM_022475.3 HHIP

Participates

as a component of

Hh-Npp:HHIP [ciliary membrane] (Homo sapiens)

as an input of

HHIP binds Hedgehog (Homo sapiens)

Inferred To

HHIP [ciliary membrane] (Bos taurus)

HHIP [ciliary membrane] (Canis familiaris)

HHIP [ciliary membrane] (Gallus gallus)

HHIP [ciliary membrane] (Sus scrofa)

Hhip [ciliary membrane] (Mus musculus)

Hhip [ciliary membrane] (Rattus norvegicus)

hhip [ciliary membrane] (Danio rerio)

hhip [ciliary membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_071920.1

ENSEMBL

ENSP00000296575, ENSG00000164161, ENSP00000408587, ENST00000296575, ENST00000434550

OpenTargets

ENSG00000164161

GeneCards

HHIP

HPA

ENSG00000164161-HHIP

PRO

Q96QV1

Pharos - Targets

Q96QV1

GlyGen

Q96QV1

PDB

2WG4, 3HO3, 7PGN, 3HO4, 2WFT, 3HO5, 7PGK, 7PGM, 2WFX, 7PGL, 2WG3

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15465 SHH	20	CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [extracellular region] (R-HSA-445140) CHOL-N-palmitoyl-L-cysteine-SHH(24-197) [endoplasmic reticulum lumen] (R-HSA-5362447) ub-N4glycoAsn-SHH(198-462) [endoplasmic reticulum lumen] (R-HSA-5362416) ub-N4glycoAsn-SHH(198-462) [cytosol] (R-HSA-5362394) 2xHC-SHH(24-462) [endoplasmic reticulum lumen] (R-HSA-5358280) N4glycoAsn-SHH(198-462) [endoplasmic reticulum lumen] (R-HSA-5358289) CHOL-SHH(24-197) [endoplasmic reticulum lumen] (R-HSA-5358296) N4glycoAsn-2xHC-SHH(24-462) [endoplasmic reticulum lumen] (R-HSA-5362384) SHH(24-462) C198S [endoplasmic reticulum lumen] (R-HSA-5358439) SHH(24-462) W117G [endoplasmic reticulum lumen] (R-HSA-5358404) SHH(24-462) H374R [endoplasmic reticulum lumen] (R-HSA-5358430) SHH(24-462) L382P [endoplasmic reticulum lumen] (R-HSA-5358428) SHH(24-462) A383T [endoplasmic reticulum lumen] (R-HSA-5358444) SHH(24-462) A376D [endoplasmic reticulum lumen] (R-HSA-5358445) SHH(24-462) P377S [endoplasmic reticulum lumen] (R-HSA-5358427) SHH(24-462) R381P [endoplasmic reticulum lumen] (R-HSA-5358425) SHH(24-462) A373T [endoplasmic reticulum lumen] (R-HSA-5358448) SHH(24-462) C198F [endoplasmic reticulum lumen] (R-HSA-5358441) SHH(24-462) G196E [endoplasmic reticulum lumen] (R-HSA-5358437) SHH(24-462) G196V [endoplasmic reticulum lumen] (R-HSA-5358433)	0.691	10

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